Abstract 1161P
Background
The Prognosis of patients with malignant central airway obstruction (MCAO) is very poor; nonetheless, the clinical outcome of bronchoscopic cryotherapy (BC) in patients with non-small cell lung cancer (NSCLC) is not well known. This study aimed to evaluate the clinical outcomes of BC and evaluate the factors associated with complication.
Methods
In this retrospective study, we reviewed the medical records of patients with NSCLC who underwent bronchoscopic cryotherapy for MCAO at Asan Medical Center, South Korea. Most sessions were conducted via flexible bronchoscopy under moderate sedation with local anesthesia. A multivariate logistic regression analysis was used to identify risk factors for complication.
Results
A BC was performed 127 sessions in 100 patients between October 2008 and December 2020. More than partial reestablishment of airway patency were achieved in 118 out of 127 sessions (92.9%), symptoms relief after BC was found in 74.6% of patients, and a recurrence was reported in 32 patients (25.2%). Most common complication was intrabronchial bleeding (44 of 127, 34.6%), but there was no severe bleeding. Univariate and multivariate logistic regression analysis revealed that diabetes mellitus (OR 4.302, 95% CI 1.534-12.065, p=0.006) was independently associated with bleeding complication.
Conclusions
Bronchoscopic cryotherapy is an efficient and relatively safe interventional procedure for patients with NSCLC related MCAO. Our finding suggested that diabetes might be a risk factor for bleeding complication.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.