Abstract 953P
Background
Hepatocellular carcinoma is the third leading cause of cancer mortality worldwide. Globally the incidence is increasing with an estimated 900,000 new cases diagnosed in 2020. This study considers the geographical trends in disease burden from hepatocellular carcinoma. Data from 1990 to 2019 is explored to further understand the pattern of disease across EU15+ nations.
Methods
Observational study of The Global Burden of Disease database. Data were for age-standardized incidence rates (ASIR), age-standardized mortality rates (ASMR) and disability-adjusted life years (DALYs) for the years 1990-2019. Mortality to incidence ratios were computed MIR (MIR). Trends were analysed over time and sex-specific absolute and percentage change values were calculated for each country between the start (1991-1993) and the end (2017-2019) of the observation period.
Results
ASIRs increased in 17/19 countries in females and 18/19 countries in males. The greatest increases in ASIR were in Ireland (+149.9%) for females and Portugal (+178.8%) for males. ASMRs increased in all countries except Italy (for both sexes) and Sweden (for females). The largest rises in ASMR were in Australia (+134.8%) for females and Portugal (+159.1%) for males. MIR decreased in all countries except Denmark in males (+8.0) and females (+1.2). Ireland saw the greatest decline in MIR among females (-15.0%) and the United Kingdom for males (-16.4%). DALYs increased in all countries except Italy for both males and females, and Sweden for females.
Conclusions
The incidence of and mortality from hepatocellular carcinoma are increasing in the majority of EU15+ countries. The rise in mortality and fall in MIR suggests that outcomes from hepatocellular carcinoma are improving, despite an increased burden of disease.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.