Abstract 160P
Background
Living with early stage HR+/HER2- BC may impact pts’ ability to work, and this may impact overall HRQoL. This study aimed to assess the relationship between pts’ employment, WPAI scores and HRQoL.
Methods
From June to October 2019, physicians in the USA, Germany and UK invited pts diagnosed with stage I-III HR+/HER2- BC receiving adjuvant therapy to complete a questionnaire including patient-reported HRQoL measures and WPAI and provided pt demographics. Mean scores for HRQoL were compared across pts who were working (full or part time) and not working (unemployed, retired, on long term sick leave) with differing WPAI scores. A higher WPAI score indicates greater work productivity and activity impairment.
Results
Questionnaires were completed by 518 pts of mean age 59 years with tumour grade 1 46%, 2 40%, 3 9%, unknown 5%; 74% node negative; 78% receiving adjuvant therapy at data abstraction. The proportion of pts working and not working varied (working: US 33%, Germany 31%, UK 22%; not working: US 35%, Germany 43%, UK 52%). Among working pts, those with greatest work productivity impairment (WPAI ≥50) had significantly lower scores for all HRQoL measures than those with the lowest productivity impairment (WPAI <20). HRQoL was lower for working pts with WPAI ≥50 than for pts who were not working, across all measures except EuroQol 5 dimension 3 level and functional assessment of cancer - breast: functional wellbeing (Table). Table: 160P
HRQoL measure* (mean) | Not working | Working | p-value | ||
n=213 | WPAI <20 n=30 | WPAI 20-49 n=56 | WPAI ≥50 n=28 | ||
EQ-5D-3L UI | 0.730 | 0.915 | 0.841 | 0.754 | <.001 |
EQ-VAS | 69.7 | 88.2 | 78.4 | 66.2 | <.001 |
FACT-B | 97.8 | 126.0 | 105.6 | 92.1 | <.001 |
FACT-G | 70.4 | 94.3 | 78.1 | 67.1 | <.001 |
FACT-B TOI | 62.8 | 82.1 | 67.7 | 60.6 | <.001 |
FACT-B BC | 27.4 | 31.8 | 27.5 | 25.0 | <.001 |
FACT-B PWB | 20.9 | 26.6 | 23.4 | 20.2 | <.001 |
FACT-B EWB | 15.4 | 20.4 | 16.9 | 12.6 | <.001 |
FACT-B FWB | 14.5 | 23.7 | 16.7 | 15.4 | <.001 |
*BC, breast cancer subscale; EQ-5D-3L, EuroQol 5 dimension 3 level; FACT-B, functional assessment of cancer-breast; EWB, emotional wellbeing, FWB, functional wellbeing; G, general; PWB, physical wellbeing; SWB, social wellbeing; TOI, trial outcome index; VAS, visual analogue scale
Conclusions
Greater work productivity impairment was associated with lower HRQoL on all measures, and HRQoL was lower in working pts with WPAI scores ≥50 than in not working pts. The difference between scores for not working pts and working pts with WPAI <20 was also clinically meaningful for all HRQoL measures. These results indicate a need to optimise care in the adjuvant BC setting to maintain pts’ ability to work, and as a result, their HRQoL.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Adelphi Group.
Funding
Adelphi Group.
Disclosure
A. Rider, R. Williams, L. Gillespie-Akar: Financial Interests, Personal, Full or part-time Employment, Full-time employee: Adelphi Real World. B. Bennett, A. Gogate: Financial Interests, Personal, Full or part-time Employment, Full-time employee: Bristol Myers Squibb.