Abstract 217P
Background
Several studies have reported that obese women with breast cancer (BC) have decreased rates of pathological complete response (pCR) compared to their leaner counterparts. However, whether the survival rates of obese women who manage to achieve pCR differ from those of non-obese patients who also achieve pCR is unclear.
Methods
Medical records of women diagnosed with BC between 2009 and 2020 in a center in Monterrey, Mexico were reviewed. Patients with stages I-III at diagnosis who received neoadjuvant chemotherapy and with at least 6 months of follow-up were eligible. Fisher’s exact tests were used to compare pCR rates between groups. Recurrence-free survival (RFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Associations between variables were explored using log-rank tests.
Results
A total of 513 women with a median age at diagnosis of 48 years (range 25-88) were included, of which 250 (49%) were obese. The median follow-up was 38 months (95%CI 34-42). Regarding pCR rates, there were no significant differences between non-obese and obese patients (28% vs. 24%, p=0.305). In non-obese women, the 3-year RFS and OS of those who achieved pCR were significantly better than in those who did not (96% vs 79% [p=0.010] and 98% vs 87% [p=0.018]). On the other hand, the 3-year RFS and OS in obese women who achieved pCR were not significantly different from those who did not (83% vs 76% [p=0.122] and 87% vs 83% [p=0.440]). Notably, the 3-year RFS and OS of non-obese and obese women who achieved pCR showed striking differences, although these were not statistically significant (96% vs 83% [p=0.190] and 98% vs. 87% [p=0.050]).
Conclusions
Remarkably, almost half of our cohort was obese. Survival rates in those who achieved pCR were not significantly hindered by obesity. However, obese patients who achieved pCR had similar outcomes to obese patients who did not.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.