Abstract 1678P
Background
Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death in women worldwide. Sarcopenia is a significant predictor of toxicity and time to progression in breast cancer patients, and chemotherapy may induce sarcopenia. Resistance exercise is a meaningful exercise prescription for sarcopenia in terms of improving muscle mass and function in elderly patients. However, there are still limited studies evaluating the effect of resistance training in decreasing muscle loss during chemotherapy. The aim of the study was to know the effect of resistance training in the prevention of sarcopenia induced by chemotherapy.
Methods
A prospective cohort study was conducted in breast cancer patients who underwent chemotherapy. Breast cancer patients who underwent chemotherapy for the first time were included. Muscle mass evaluation using Bio-impedance analysis (BIA) and muscle strength evaluation using hand grip dynamometer JAMAR were done before chemotherapy. Subjects who had sarcopenia before chemotherapy were recommended to have resistance training. Muscle mass and function were then evaluated after three cycles of chemotherapy. Sarcopenia was identified if they had both decreased muscle mass and function.
Results
A total of 42 women breast cancer patients were included in the study. The mean age was 47.98+7.54 years old. Most subjects were of normal body mass index, 90.5% subjects were in ECOG functional status criteria, 73.8% were in stage 2 disease, 52.4% had menopause, and 71.4% subject received taxane-based chemotherapy, fourteen (30.3%) subjects had sarcopenia before chemotherapy, and had done resistance training with medical rehabilitation during chemotherapy. After 3 cycles of chemotherapy, there were statistical differences in mean of muscle mass and muscle function. At the end of 3 cycles of chemotherapy, only one subject had sarcopenia, the others had categorized normal muscle mass or function.
Conclusions
The effect of resistance training in breast cancer during chemotherapy was protective to muscle mass and function. It also could reverse muscle mass and function after 3 cycles of chemotherapy.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.