Abstract 393P
Background
Patients with colorectal cancer (CRC) may somehow receive insufficient preoperative colonoscopy, e.g. as a result of intestinal obstruction or inadequate intestinal preparation. However, updated guidelines do not recommend the timing of surveillance colonoscopy to be performed for those patients. The purpose of this study was to identify risk factors for CRC complicated with synchronous advanced adenomas.
Methods
We conducted a retrospective analysis of 4659 patients with CRC from the year of 2015 to 2018. Advanced adenoma was defined as adenoma ≥ 10 mm, villous or tubulovillous component or high-grade dysplasia. The patients with full clinical and pathological information were divided into no adenoma group, non-advanced adenoma group and advanced adenoma group. Univariate and multivariate logistic regression analysis were used to estimate odds ratio (OR) and 95% confidence interval (CI) for all potential risk factors.
Results
Among those eligible patients, 675 cases (14.5%) were found to be advanced adenomas, while 848 (18.2%) were found to be non-advanced adenomas. As compared with no adenoma group, CRC patients with synchronous advanced adenomas were more likely to be over 50 years old (OR=3.00, P<0.001), male (OR=2.13, P<0.001), have primary tumor located in the right colon (OR=1.82, P<0.001) and multiple primary cancers (OR=3.05, P<0.001), with NRAS mutant (OR=1.71, P=0.03) and with BRAF wild type (OR=2.55, P=0.03). There was no difference in risk factors between non-advanced adenoma group and advanced adenoma group.
Conclusions
The study illustrated several risk factors of CRC patients with synchronous advanced adenomas. Intense surveillance for CRC patients complicated with high-risk polyps is of great significance to prevent synchronous CRC.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.