Abstract 773P
Background
Epithelial ovarian cancer (EOC) is commonly regarded as the deadliest gynecological cancer, and the demand for novel noninvasive prognostic biomarkers remains significant. This study aimed to investigate the prognostic value of preoperative blood biomarkers in EOC patients and the correlation of IL2RA mRNA expression with the tumor immune microenvironment (TIME).
Methods
A total of 73 patients who had undergone surgery for an ovarian mass were included in this study. Serum concentrations of blood biomarkers, including soluble interleukin 2 receptor α (sIL-2R), were measured 1-2 weeks before surgery. Independent prognostic factors for progression-free survival (PFS) were investigated with multivariate Cox regression analysis. A prognostic model was subsequently developed and evaluated in terms of discrimination, calibration and clinical net benefit. Furthermore, transcriptome data of 376 EOC cases from The Cancer Genome Atlas (TCGA) analyzed with ESTIMATE and CIBERSORT computational methods to evaluate the correlation of IL2RA mRNA expression with TIME.
Results
The sIL-2R concentration was positively correlated with advanced stage and negatively correlated with PFS. A high sIL-2R concentration was found to be the only significant prognostic blood biomarker for PFS by multivariate Cox regression analysis. A prognostic nomogram was developed with satisfactory discrimination, calibration and clinical net benefit. ESTIMATE analysis of TCGA transcriptome data demonstrated that higher IL2RA expression was significantly associated with higher immune scores. And CIBERSORT analysis of the tumor-infiltrating lymphocytes (TILs) profile demonstrated that IL2RA expression was positively correlated with activated CD4+ T cells, M2 macrophages and resting dendritic cells in EOC.
Conclusions
sIL-2R is a potential prognostic immune biomarker for EOC patients, and a comprehensive prognostic model comprising sIL-2R with satisfactory discrimination and clinical appliance was developed. sIL-2R may also play a vital role in the EOC immune response by regulating immune cell infiltration. Therefore, we recommend routinely measuring sIL-2R in EOC patients.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.