Abstract 1737P
Background
The range of cardiovascular risks in cancer patients is diverse. Patients with metastatic/distant illness at the time of diagnosis have the highest standard mortality rate of fatal heart attack than do regional and localized staged patients. We wanted to investigate the pattern of distant sites (bone, brain, liver, and lung metastases) and subsequent survival of patients with heart-related deaths from all cancer forms.
Methods
We conducted a Surveillance, Epidemiology, and End Results (SEER) registry-based investigation (2010-2016) and collected data on cancer patients with advanced stages who died from cardiac events. For survival analysis, the Kaplan-Meier technique was used, and a multivariate model was created by controlling for multiple confounding factors.
Results
We extracted 6021 distant cancer patients who experienced fatal heart death. Distant lung cancer was predominantly seen with a higher percentage of fatal heart attack rate than orodigestive tract and bone marrow (33.7%, 19%, 16.2%). In the study difference of survival between the metastatic sites in lung, the liver metastasis reveals worse survival than others (p=>0.0001; median months: 2 vs. 1 month). Further adjusted variables by multivariate model, the lung metastases showed favorable survival than liver mets site (P=<0.000, 1.395(1.244-1.564).
Conclusions
Most cases of metastasis in heart-specific death patients were reported in lung cancer sites. While liver metastasis was associated with worse prognosis, the metastasis to lung was related to greater survival than other metastatic locations. More research is needed to predict the prognosis of distant patients and the related cardiac morbidity and mortality.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.