Abstract 362P
Background
The analysis of the effect of ABCG2 transporters on the effects of photodynamic therapy in malignant gliomas was carried out.
Methods
A total of 98 patients with a glial tumor of supratentorial localization, a high degree of tumor anaplasia according to Grade (III-IV), were treated at the RNSI prof. A.L. Polenov. The analysis of the expression level of ABCG2 transporters and the effect on median survival during PDT was carried out. Chlorin e6 was used for PDT; the source of laser radiation was Latus 2.5 with a wavelength of 662 nm and a maximum power of 2.5 W.
Results
Data are presented that glioma malignant cells are characterized by high expression of several ABCG2 transporters. It is also presented that gene expression of these transporters can correlate with the effects of ongoing photodynamic therapy and chemotherapy and affect the survival rate in patients with gliomas, and can be used as a prognostic biomarker. Median survival of patients with Grade III gliomas up to 42.1 ± 4.1 months with low expression of ABCG2 transporter (with high expression of ABCG2 - 18.3 ± 3.9 months), for patients with Grade IV gliomas up to 22.7 ± 3.5 months with low expression of ABCG2 carrier (with high expression of ABCG2 - 11.6 ± 1.9 months) (P = 0.0001).
Conclusions
Malignant gliomas are characterized by various genetic and epigenetic aberrations, the influence of the microenvironment on the tumor, and the presence of cancer stem cells (CSCs), which make the tumor more aggressive, invasive, and resistant to treatment methods. A significant role in this complex process is played by ABCG2 transporters localized in tumor cells.
Clinical trial identification
The study was carried out in accordance with the Helsinki Declaration.
Legal entity responsible for the study
The authors.
Editorial acknowledgement
Has not received any funding.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.