Abstract 351P
Background
Glioblastoma multiform is the most common malignancy and very aggressive tumor found in the central nervous system. The current standard treatment for glioblastoma includes maximal safe resection followed by adjuvant concurrent chemo-radiation and adjuvant chemotherapy. With its aggressive behavior, delayed adjuvant therapies may lead to worse survival outcome that is showed by data from other tumors such as breast cancer and lung cancer. However, the relationship between timing to initiation post-operative adjuvant chemo-radiotherapy in glioblastoma remains unclear.
Methods
A literature search was conducted on 5 databases by 2 persons. Bias assessment for individual studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale by 2 independent reviewers.
Results
Total of 2,804 studies were found from initial database search. Twenty studies met eligibility criteria and were reviewed. Nine studies found no statistically significant effects of time to initiation post-operative adjuvant chemo-radiotherapy on overall survival. On the other hand, eleven studies found statistically significant effects of time to initiation post-operative adjuvant chemo-radiotherapy on overall survival.
Conclusions
Time to initiation adjuvant chemo-radiotherapy is a challenging issue. Most of the studies reported that slight delayed (4-6 weeks) timing to initiation of chemo-radiation seems to have a better survival outcome.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Directorate of Research and Community Engagement, Universitas Indonesia.
Disclosure
All authors have declared no conflicts of interest.