Abstract 1453P
Background
Effective interventions to improve prognosis in non-small cell lung cancer (NSCLC) are urgently needed. We assessed the effect of the early integration of interdisciplinary supportive care for patients with NSCLC on the quality of life, psychological state, cancer pain and nutritional status.
Methods
We randomly assigned (1:1) patients with newly diagnosed NSCLC receive either early interdisciplinary supportive care (ESC) integrated with standard oncologic care or standard oncological care (SC) alone. Quality of life and psychological state were assessed at baseline and at 6 months with the use of the Functional Assessment of Cancer Therapy-Lung (FACT-L) scale, the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-9 (PHQ-9), respectively. Cancer pain and nutritional status were assessed with the use of the Numerical Rating Scale (NRS) and Patient-Generated Subjective Global Assessment (PG-SGA), respectively.
Results
From Oct 15, 2019, to Jun 12, 2020, 60 patients were enrolled: 30 in ESC group and 30 in the SC group. Compliance at 6 months was 77% (23 patients) in the ESC group versus 73% (22) in the SC group. Patients assigned to ESC group had a better quality of life than did patients assigned to SC group (mean score on the FACT-L scale, 122.3.0 vs. 113.0; P = 0.0007). In addition, fewer patients in the ESC group than in the SC group had anxiety (mean score on the HADS Anxiety subscale, 1.13 vs 2.86, P = 0.0005) and depressive (mean score on the HADS Depression subscale, 0.65 vs 3.56, P ＜0.0001) symptoms. The PHQ-9 results showed that 100% patients were free of depression in the ESC group versus 45.5% patients were free of depression, 55.5% had mild level (score 5-9) in SC group (P ＜0.0001). Furthermore, patients in the ESC group (moderate malnutrition was 60.9% and mild malnutrition was 39.1% according to PG-SGA) than in the SC group (severe malnutrition was 40.9%, moderate malnutrition was 50.0% and mild malnutrition was 9.1% according to PG-SGA) had a better nutritional status (P=0.001).
Conclusions
Among patients with non-small cell lung cancer, early integration of interdisciplinary supportive care led to significant improvements in quality of life, psychological state and nutritional status.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
H. Yu.
Funding
Research Support from: Chongqing Talents Innovation Leading Talents Program (No.CQYC201903078); Key Project of the Climbing Funding of the National Cancer Center (No.NCC201822B74).
Disclosure
All authors have declared no conflicts of interest.