Abstract 878P
Background
Chemoradiation (CRT) is the standard of treatment of patients with locally advanced carcinoma (Ca) larynx with intact cartilage and functional larynx. Patients who not eligible for chemoradiation are treated by Radical radiotherapy (RT).
Methods
This is a retrospective analysis of patients treated with CRT or RT alone for stage III or stage IVa Ca larynx from January 1st, 2006 to December 31st, 2015. The patients treated with radiation treatment alone, induction chemotherapy followed by radiation treatment, concurrent chemoradiation, and induction chemotherapy followed by concurrent chemoradiation were included in the study. The endpoints were to assess the overall survival (OS) and disease-free survival (DFS).
Results
The total number of patients included in the study was 630. The majority of the patients were between 50 to 70 years of age (477, 75.7%). The majority of the patients were males (601, 95.4%). A total of 367 patients (58.1%) had stage III disease at presentation followed by stage IVa (240, 38.3%) and IVb (23, 3.6%). The median follow-up period for the entire group of 630 patients was 59 months [2-175months]. A total of 549 patients (87.1%) had a complete response. Eleven patients underwent salvage surgery for residual disease. At a median follow-up of 59 months, 134 patients (21.2%) relapsed. Salvage surgery was done for 21 patients with recurrence. Thirty patients underwent salvage laryngectomy for residual/recurrence. The 5 year OS and DFS of the entire group were 48.7% and 45.7% respectively. The stage-wise 5 year OS were 58.9%, 34.9% and 30.4% for stage III, IVa, IVb respectively (p value=0.001). The OS rates and DFS rates for various treatment groups; RT alone, induction chemotherapy followed by radiation treatment, concurrent chemoradiation and induction chemotherapy followed by concurrent chemoradiation were 47.6%, 62.5%, 48.6% and 48.9% respectively and 46.8%, 50%, 45.7% and 43.9% respectively.
Conclusions
This retrospective study analyzed patients who received chemoradiation/radiation in patients with locally advanced carcinoma larynx. DFS and OS were comparable with published literature.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.