Abstract 1568P
Background
COVID-19 reinfection has been increasingly reported. Immunocompromised patients may be more susceptible to COVID-19 reinfection due to impaired immune responses to the virus. The current study aimed to evaluate the clinical and laboratory outcomes of solid cancer patients who were reinfected with COVID-19.
Methods
Patients with a diagnosis of solid cancer and COVID-19 PCR positive were screened. The patients enrolled whether patient has at least one negative COVID-19 PCR test and clinical improvement. In addition to that at least 28 days after the previous positive COVID-19 PCR result, the patient must have a confirmed COVID-19 PCR positive result again.
Results
Total 1024 patients with COVID-19 PCR positive solid malignancy were screened. Thirty-two patients were included in the study. The median time between the first COVID-19 infection and reinfection was 46 (30-194) days. The reinfection rate was 3.1%. The most common cancer subtype was lung cancer. Mortality rate of reinfection was 34.3% (n=11). Ferritin and creatinine values of serum parameters in reinfection were found to be significantly higher compared to the first infection, respectively (p:0.015, p:0.014). Nine patients with only 1 comorbidity had higher mortality (p=0.052). During reinfection period rate of patients hospitalized in intensive care unit was significantly higher compared with rate of patients during first COVİD-19 infection (p:0.002). The mortality rate in 8 patients using antiaggregant or anticoagulant for a long time was not statistically different from the group who did not use it (p:0.681).
Conclusions
Solid cancer patients have a higher mortality rate in COVID-19 reinfection. The reinfection rate was 3.1%. This study demonstrated one of the first preliminary clinical results of COVID-19 reinfection in solid cancer patients.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Oktay Ünsal.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.