Abstract 843P
Background
Ocular adnexal lymphomas (OAL) are rare tumors arising in the eyelid, conjunctiva, lacrimal apparatus or orbit. The most frequent subtype is extranodal marginal zone lymphoma of mucosal associated lymphoid tissue (MALT). Bilateral disease, primary site, histology and stage at diagnosis affect prognosis.
Methods
Retrospective study characterizing the epidemiology and outcomes of OAL diagnosed patients (pts) in our center from 2005 to 2021. Overall (OS) and progression free survival (PFS) were calculated by the Kaplan Meier method.
Results
From 2005 to 2021 45 pts with OAL were included. Median age at diagnosis was 67 yo (8-97) and female: male ratio 1,65. Only 2 pts had bilateral disease and the most common sites were orbit (37,8%) and eyelid (33,3%). All pts had B-cell lymphomas and most presented with MALT (71,1%) and stage IE (73,3%). A complete response to treatment (CR) occurred in 71,1% pts and a 1st recurrence in 28,9% (after a median of 24,6 months, 0-127,4). Median follow-up was 50 months (mo) (1,7-173,9), median PFS was 29,5 mo (0-127,4) and median OS was 41,5 mo (1,8-101,6). Gender (p = 0,151), lymphoma subtype (p =0,588), primary site (p = 0,651), stage (p = 0,116), combined versus non-combined treatment (p = 0,792) and CR versus non-CR (p = 0.203) did not influence PFS. Conversely, indolent subtypes (p = 0,005), stage IE (p = 0,000) and CR (p = 0,020) positively influenced OS but gender (p = 0,278), primary site (p = 0,626) and combined versus non-combined treatment (p = 0,619) did not. Table: 843P
| OAL n (%) | MALT n (%) | |
| Number of patients | 45 (100) | 32 (71,1) |
| Histology Aggressive* Indolent** | 6 (13.3) 39 (86.7) | -- -- |
| Stage at diagnosis IE IIE IVE | 33 (73,3) 2 (4,4) 10 (22,2) | 24 (75) 0 (0) 8 (25) |
| Treatment RT (Imuno)chemotherapy+RT Surgery Combined treatment* Other | 12 (26,7) 20 (44,4) 4 (8,9) 6 (13,3) 3 (6,7) | 9 (28,1) 13 (40,6) 4 (12,5) 3 (9,4) 3 (9,4) |
| PFS | 29,5 mo (0-127,4) | 26,9 mo (0-127,4) |
| OS | 41,5 mo (1,8-101,6) | 50,0 mo (23-72,8) |
*Diffuse Large B cell, Mantle cell and Lymphoblastic Lymphoma **MALT, Follicular ***More than one modality
Conclusions
OAL are more frequent in the 6th and 7th decades and in female pts. Orbit and eyelid are the most common primary sites. MALT is the most common subtype and most pts present with localized disease, with favorable outcomes.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.