Abstract 1127P
Background
Oncogeriatrics is a discipline that combines the skills of oncology and geriatrics to serve elderly patients with cancer. In the absence of geriatrician in our country, it would be useful in the current situation to try to introduce in our daily practice some elements of the global geriatric assessment (CGA) like the CARG predictive score of chemotoxicity. The present study aimed to verify feasibility and compare the value of CARG score with the results of chemotoxicity.
Methods
A prospective study was conducted in old patients with cancer. Before chemotherapy treatment, a geriatric assessment was done and the CARG score was calculated for each patient. The chemotherapy-related toxicity was collected on the basis of the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE; version 4.0). The results of the CARG score were compared with the toxicity described by the patients.
Results
One hundred and forty-two patients were treated with chemotherapy. Mean age was 71 years. Colorectal cancer (34.7%) was the most common localization followed by lung cancer (31.9%). 100 patients have one or two comorbidities of which 90 were taking less than 3 medications. Most patients (57%) had a good ECOG performance statute (ECOG PS 1). Patients were in low, intermediate and high-risk of severe chemotherapy toxicity in 14.5; 51.5 and 30% respectively. 1067 chemotherapy treatment according to 48 chemotherapy protocols were administered. 75% of cases of patients received a poly chemotherapy. Severe toxicity (grade 3-5) were noted in 82 patients. The most common grade 3-5 non-haematological toxicities were fatigue (43), diarrhea (32) and anorexia (27). The hematological toxicities (grade 3-5) were leukopenia (32) and neutropenia (64). For the CARG toxicity score, rates of severe adverse events in low, intermediate and high-risk groups were 11.8%, 33.3% and 15.5 % respectively. The frequency of severe chemotherapy toxicity in the different risk groups according to the CARG toxicity scores were independent there was no statistically significant association between them, χ2=0.68; p=0.71.
Conclusions
In our study the CARG toxicity predictive tool could not effectively estimate the occurrence of severe toxicity related to chemotherapy.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Miraoui Dalila.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.