Abstract 1681P
Background
Physical fitness is a set of attributes which facilitate to do the physical tasks of everyday living. The health-related components of fitness include: (1) morphological component (body mass, body composition etc), (2) muscular component (muscular strength, muscular endurance) and (3) cardio-respiratory component (submaximal exercise capacity, maximal aerobic power, heart function, etc). Physical fitness depends on genetic factors, recent physical activity (PA) and comorbidities. We previously examined the associations of PA with biomarkers and only found association between vigorous PA and neutrophil-lymphocyte ratio (NLR). No associations between C reactive protein (CRP) and PA were found.
Methods
BCS older than 18 yo who had finished their treatment and were able to walk a mile. BMI, waist, and hip perimeter were used to assess body composition. Cardio-respiratory fitness was assessed using the one-mile walk test. Then, VO2peak was estimated according to Kline equation. Handgrip strength (superior muscular strength) was measured using a dynamometer. The sit to stand test (inferior muscular strength) measures the seconds required to perform five consecutive repetitions of sitting down and uprising. Biomarkers potentially related to PA were analysed, namely estrogens, progesterone, testosterone, androsterone, insulin, IGF-I, IGBBP-3, NLR, CRP, cortisol.
Results
84 BCS were recruited. Testosterone levels were associated with recovery heart rate. Insulin levels were inversely associated with estimated VO2peak, gait speed and basal heart rate. CRP was inversely associated with VO2peak, gait speed, inferior muscular strength. CRP was positively associated with BMI and hip perimeter.
Conclusions
CRP (but not NLR) was associated with all the domains of physical condition, namely cardiorespiratory fitness, muscular strength, and adiposity. Insulin (but not IGF-I, IGBBP-3) was associated with the cardiorespiratory component. Some biomarkers such as CRP and insulin could be modified by physical condition more than by physical activity. Plasmatic CRP levels have been associated with risk of CV disease. Improving the physical condition of BCS could be useful to improve the CV risk in BCS, which continues to be the most important cause of death in this population.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
A. Ruiz-Casado.
Funding
SEOM (Spanish Society of Medical Oncology) - Font-Vella.
Disclosure
All authors have declared no conflicts of interest.