Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Display session 2

5085 - Usefulness of NT-ProBNP as a biomarker of cardiotoxicity in breast cancer patients treated with trastuzumab


29 Sep 2019


Poster Display session 2


Tumour Site

Breast Cancer


Isabel Blancas López-Barajas


Annals of Oncology (2019) 30 (suppl_5): v55-v98. 10.1093/annonc/mdz240


I. Blancas López-Barajas1, C. Martín2, F.J. Martín-Pérez2, M. Legerén1, M. Martos2, S. Sequero1, S. Carnenero1, M.E. Pérez-García1, C.J. Rodríguez-González1, J.M. Jurado1, M. Delgado1, B. González-Astorga1, I. González-Cebrián1, J.M. Garrido3, C. Prieto1, V. Bayo-Martin1, M.I. Fernández-Gutiérrez1, G. Ayala-Carbonero4, S. Reyes-Larzategui5, F. Rodríguez-Serrano6

Author affiliations

  • 1 Oncology Unit, San Cecilio University Hospital, 18016 - Granada/ES
  • 2 Department Of Medicine, University of Granada, 18016 - Granada/ES
  • 3 Department Of Surgery, University of Granada, 18016 - Granada/ES
  • 4 Department Of Radiology, San Cecilio University Hospital, 18016 - Granada/ES
  • 5 Department Of General Surgery, San Cecilio University Hospital, 18016 - Granada/ES
  • 6 Institute Of Biopathology And Regenerative Medicine, University of Granada, 18016 - Granada/ES


Login to get immediate access to this content.

If you do not have an ESMO account, please create one for free.

Abstract 5085


Trastuzumab is a highly efficient drug in HER2-positive breast cancer that increases patient survival. Due to cardiotoxicity is the most important side effect of trastuzumab treatment, cardiac monitoring should be a priority, especially in the presence of comorbidities. Left ventricle ejection fraction (LVEF) determination remains the most used technique to diagnose cardiotoxicity in clinical practice. The purpose of this study is to analyse the usefulness of NT-ProBNP as a biomarker of cardiotoxicity in breast cancer patients treated with trastuzumab.


The study included 66 patients who received trastuzumab. We collected the LVEF and NT-proBNP values measured during the course of treatment, and cardiovascular risk factors including diabetes, hypertension, smoking, hypercholesterolemia and BMI. Cardiotoxicity was diagnosed during the follow-up program considering a decrease of the LVEF from baseline or clinical manifestation of congestive heart failure. According to the literature, NT-proBNP cut-off points were considered to stablish normal or abnormal values in terms of patent age.


174 paired LVEF/NT-proBNP values were found. 27.3% of patients suffered cardiotoxicity during trastuzumab treatment and most of cases were diagnosed based on cardiac symptomatology (66.7 %). Logistic regression analysis of NT-proBNP and the cardiovascular risk factors showed a significant association of diabetes mellitus (OR 5.9, 95% CI 1.2 - 28.5, p = 0.028) and NT-proBNP (OR 22.0, 95% CI 5.7 - 85.4, p = 0.000) with the development of cardiotoxicity during trastuzumab treatment, whereas the other variables were not statistically significant.


Diabetes and NT-proBNP values seem to be associated with an increased risk of cardiotoxicity in breast cancer patients during trastuzumab treatment. In diabetics, glycaemic control and a more intense cardiac monitoring could provide objective benefits during the treatment. Moreover, NT-proBNP determination could become an accessible way to evaluate cardiac risk in this context.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.


Has not received any funding.


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.