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Poster Display session 2

3736 - Safety of hypofractionated whole breast irradiation after conservative surgery for patients aged less than 60 years: a multi-center comparative study.


29 Sep 2019


Poster Display session 2


Tumour Site

Breast Cancer


Icro Meattini


Annals of Oncology (2019) 30 (suppl_5): v55-v98. 10.1093/annonc/mdz240


I. Meattini1, L. Livi1, K. Kim2, J. Kim2, W. Jung2, E. Olmetto1, I. Desideri1, C. Saieva3, C. Becherini1, V. Salvestrini1, A. Fourquet4, Y. Kirova4, P. Poortmans4

Author affiliations

  • 1 Department Of Biomedical, Experimental, And Clinical Sciences, University of Florence, 50134 - Firenze/IT
  • 2 Radiation Oncology, Ewha Womans University College of Medicine, 07985 - Seoul/KR
  • 3 Cancer Risk Factors And Lifestyle Epidemiology Unit, Institute for cancer research, prevention and clinical network (ISPRO), Firenze/IT
  • 4 Radiation Oncology, Institut Curie, 75005 - Paris/FR


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Abstract 3736


For decades, conventionally fractionated whole breast irradiation (CF-WBI) was used after breast conserving surgery (BCS). Pivotal phase 3 trials on hypofractionated-WBI (HF-WBI) showed its non-inferiority as compared to CF-WBI. However, younger patients (<60 years) are not currently worldwide treated with HF-WBI. The aim of this multi-center comparative study is to confirm the safety of HF-WBI in a real-life series of younger patients.


Between 2010 and 2016, a total of 786 patients aged less than 60 years old with early stage breast cancer were treated with postoperative WBI after BCS in three breast cancer centers: 340 underwent HF-WBI while 446 were treated with CF-WBI. Acute toxicity was evaluated at the end of WBI. Late toxicity was evaluated at 6, 12, 24, and 36 months.


At univariate logistic analysis, hypofractionation showed a significant protective effect in terms of acute edema (p = 0.0001), acute wet desquamation (p = 0.009), chronic edema (p = 0.0001), chronic erythema/pigmentation (p = 0.0001), and breast fibrosis (p = 0.0002). At multivariate logistic analysis, hypofractionation was independent significant factor for acute edema (OR 0.09, 95% CI 0.02 to 0.48; p = 0.005), acute wet desquamation (OR 0.07, 95% CI 0.009 to 0.59; p = 0.014), and chronic edema (OR 0.18, 95% CI 0.04 to 0.75; p = 0.018). Significant association between individual characteristics and toxicity (grade 2 or more) are summarized in Table.Table:


ToxicityNProtective factorp-valueOR (95%CI)Risk factorp-valueOR (95%CI)
Acute edema43Hypofractionation Dmax/Prescribed dose° <107%0.0001 0.0010.09 (0.03-0.30) 0.16 (0.06-0.46)Chemotherapy0.0022.63 (1.42-4.90)
Chronic edema50Hypofractionation Dmax/Prescribed dose° <107%0.0001 0.0030.20 (0.09-0.44) 0.31 (0.14-0.66)EIC presence Boost dose >10 Gy Breast size >492 cc0.0001 0.032 0.0033.0 (1.66-5.46) 9.02 (1.21-67.45) 2.67 (1.41-5.05)
Acute erythema/ pigmentation163HER2 positive status Trastuzumab0.002 0.0220.30 (0.14-0.63) 0.39 (0.18-0.87)Smoking habits Boost dose >10 Gy Breast size >492 cc0.001 0.038 0.0022.14 (1.37-3.32) 2.60 (1.06-6.41) 1.78 (1.24-2.54)
Chronic erythema/ pigmentation110Hypofractionation Dmax/Prescribed dose° <107%0.0001 0.0010.40 (0.25-0.63) 0.45 (0.28-0.73)EIC presence Positive FSM Boost dose >10 Gy Breast size >492 cc0.0001 0.002 0.007 0.0342.39 (1.54-3.71) 3.47 (1.56-7.71) 15.43 (2.08-114.3) 1.58 (1.04-2.41)
Acute wet desquamation20Hypofractionation Dmax/Prescribed dose° <107%0.009 0.0470.14 (0.03-0.61) 0.29 (0.08-0.99)---
Breast fibrosis117Hypofractionation Tumor grade Ki67 index Dmax/Prescribed dose° <107%0.0002 0.022 0.023 0.0170.44 (0.29-0.68) 0.53 (0.31-0.92) 0.60 (0.38-0.93) 0.58 (0.37-0.91)EIC presence Boost dose >10 Gy Breast size >492 cc0.0001 0.022 0.00013.03 (1.99-4.62) 6.76 (2.04-22.45) 2.84 (1.83-4.41)


HF-WBI showed significantly improved toxicity outcomes in terms of both acute skin edema and wet desquamation, and chronic skin edema. HF-WBI after BCS should replace CF-WBI independently of age.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.


Has not received any funding.


All authors have declared no conflicts of interest.

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