Abstract 2085
Background
Donor lymphocyte infusions (DLI) become one of the currently used approaches to treat post-transplant relapses. However, the wide use of the different DLI strategies, its effectivity and toxicity are still unpredictable in many patients. We evaluated the impact of DLI for patients with myeloid neoplasms experienced relapse post hematopoietic stem cell transplantation (HSCT).
Methods
This study included patients with myeloid neoplasms who received DLI post HSCT at the BMT unit, Children Cancer Hospital Egypt (CCHE-57357) from 2009 to 2017. DLI was given for patients with either rising minimal residual disease (MRD) or after systemic chemotherapy for those who experienced frank relapse.
Results
A total of 20 patients received post HSCT DLI were analyzed, with median age of 7 years. About 12 patients (60%) had acute myeloid leukemia (AML), 5 with chronic myeloid leukemia (CML) and 3 cases had myelodysplastic syndrome (MDS). Seven patients had frank relapse and given systemic chemotherapy followed by DLI upon complete remission, while 13 patients received only DLI due to rising MRD. Early relapse (during 1st year) was reported in 14 cases (70%) and 7 patients relapsed beyond 1st year post-transplant. Regarding the graft status at relapse, 15 patients had maintained complete chimera while 5 patients showed mixed chimera. The one-year disease free survival (DFS) and overall survival (OS) post DLI for the whole cohort were 54% and 64%, respectively with one patient had a non-relapse mortality and 6 patients developed graft versus host disease (GvHD) post DLI. According the initial diagnosis, DFS at one year was 80% for CML, 66% for MDS and 41% for AML patients. Also DFS was better for those with late relapse (70% vs 57% for early relapse) and for those who developed GvHD post DLI.
Conclusions
DLI was associated with a durable efficacy and low toxicity in pediatric patients with hematologic malignancies. However, larger studies and standardized approaches are required to identify the outcome predictors of this treatment modality.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
592 - Effects of novel targeted anticancer drugs on cytotoxicity, apoptosis, angiogenesis, EMT, drug resistance and autophagic mechanism
Presenter: Seyma Aydinlik
Session: Poster Display session 1
Resources:
Abstract
3235 - Delineating the mechanisms of alpha 1-3 fucosyltransferase FUT11 in ovarian cancer
Presenter: Qi Chen
Session: Poster Display session 1
Resources:
Abstract
3577 - The tyrosine kinase inhibitor Dasatinib blocks tumor growth, invasion and recurrence potential by interrupting the communication between cancer cells and their surrounding microenvironment in triple negative breast cancer
Presenter: Miriam Nuncia-Cantarero
Session: Poster Display session 1
Resources:
Abstract
4808 - NORE1A induces a feedback termination of TNF signaling by antagonizing TNFR1 through ITCH-mediated destruction complex
Presenter: Jieun Ahn
Session: Poster Display session 1
Resources:
Abstract
1294 - Hsp90 inhibitors enhance the antitumoral effect of osimertinib and overcome osimertinib resistance in non-small-cell cell lung cancer cell models
Presenter: Jordi Codony-Servat
Session: Poster Display session 1
Resources:
Abstract
1559 - Expression of IL-17RA promotes cancer stem-like properties of colorectal cancer cells by Stat3 activation
Presenter: Chih-Yung Yang
Session: Poster Display session 1
Resources:
Abstract
1615 - Adaption of Pancreatic Cancer Cells to AKT1 Inhibition Induces the Acquisition of Cancer Stem-Cell Like Phenotype Through Upregulation of Mitochondrial Functions
Presenter: Hugo Arasanz
Session: Poster Display session 1
Resources:
Abstract
4793 - Bub3 is phosphorylated by the Ataxia-Telangiectasia Mutated Kinase in mitosis and required for activation of the mitotic spindle checkpoint in Breast Cancer
Presenter: Mingming Xiao
Session: Poster Display session 1
Resources:
Abstract
1448 - The regulation of INK4 locus by long non-coding RNAs
Presenter: Yojiro Kotake
Session: Poster Display session 1
Resources:
Abstract
1858 - Vascular Endothelial Growth Factor in Colorectal Cancer Pathology, Survival and Treatment
Presenter: Liz Baker
Session: Poster Display session 1
Resources:
Abstract