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Poster Display session 2

4499 - FGFR1 and CCND1 gene amplifications are associated with breast cancer resistance to aromatase inhibitors


29 Sep 2019


Poster Display session 2


Tumour Site

Breast Cancer


Evgeny Imyanitov


Annals of Oncology (2019) 30 (suppl_5): v104-v142. 10.1093/annonc/mdz242


E. Imyanitov1, M. Kramchaninov2, T. Akhapkina1, T. Sokolova1, S. Aleksakhina1, A. Togo1, A. Iyevleva1

Author affiliations

  • 1 Department Of Tumor Growth Biology, N.N. Petrov Institute of Oncology, 197758 - St.-Petersburg/RU
  • 2 Department Of Therapy, St.-Petersburg City Cancer Center, 197758 - St.-Petersburg/RU


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Abstract 4499


Several lines of evidence suggest the involvement of CCND1 and FGFR1 genes in determining breast cancer (BC) resistance to endocrine therapy, however these assumptions still require a validation in clinical data sets.


This study included 138 tumors from patients with metastatic BC who received first-line endocrine therapy with aromatase inhibitors (AI, n = 69), tamoxifen (n = 65), goserelin (n = 2) or a combination of goserelin and tamoxifen (n = 2). DNA extracted from formalin-fixed paraffin-embedded archival specimens was tested for CCND1 and FGFR1 amplification by digital droplet PCR.


CCND1 and FGFR1 status was successfully determined in 134 tumors. CCND1 and FGFR1 amplification was detected in 24 (18%) and 28 (21%) informative cases, respectively; 9 carcinomas had concurrent alterations of two genes. Amplifications were more common in less differentiated tumors (G1: 1/18 (6%) vs. G2-3: 34/86 (40%); p = 0.005, Fisher’s exact test). Median disease-free survival in patients receiving AI with CCND1 amplification was shorter than in cases with the normal gene status (12.3 vs. 14.9 months; p = 0.014, log rank test). Objective response to aromatase inhibitors was observed in 2/13 (15%) BC with FGFR1 amplification compared to 22/46 (48%) tumors with the normal FGFR1 gene copy number (p = 0.054). Noteworthy, among patients receiving AI, CCND1 and/or FGFR1 amplification occurred in 5 out of 7 (71%) women with progressive disease compared to only 4 in 23 (17%) patients with objective response to therapy (p = 0.01). Meanwhile, none of 5 tumors showing resistance to tamoxifen harbored CCND1 or FGFR1 amplification.


The presence of CCND1 and/or FGFR1 amplification is associated with worse results of AI therapy in breast cancer patients.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.


Russian Foundation for Basic Research (grant 17-04-01281).


All authors have declared no conflicts of interest.

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