Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Display session 3

2548 - Excess weight and efficacy of anti-PD-1 antibodies in advanced cancer patients


30 Sep 2019


Poster Display session 3



Tumour Site


Jacobo Rogado


Annals of Oncology (2019) 30 (suppl_5): v475-v532. 10.1093/annonc/mdz253


J. Rogado1, N. Romero Laorden2, J.M. Sanchez Torres2, A. Ramos-Levi3, V.E. Pacheco-Barcia2, A.I. Ballesteros Garcia2, R. Arranz4, A. Lorenzo5, P. Gullon6, A. Garrido2, J.M. Serra7, O. Donnay2, M. Adrados8, P. Costas2, J. Aspa9, A. Alfranca10, R. Mondejar2, R. Colomer Bosch2

Author affiliations

  • 1 Medical Oncology, Hospital Universitario de La Princesa / HU Infanta Leonor, 28006 - Madrid/ES
  • 2 Medical Oncology, Hospital Universitario de La Princesa, 28006 - Madrid/ES
  • 3 Endocrinology, Hospital Universitario de La Princesa, 28006 - Madrid/ES
  • 4 Hematology, Hospital Universitario de La Princesa, 28006 - Madrid/ES
  • 5 Hematology, Hospital General de Segovia, Segovia/ES
  • 6 Social And Cardiovascular Epidemiology Research Group, Alcala University, Alcala de Henares/ES
  • 7 Pharmacy, Hospital Universitario de La Princesa, 28006 - Madrid/ES
  • 8 Pathology, Hospital Universitario de La Princesa, 28006 - Madrid/ES
  • 9 Pneumonology, Hospital Universitario de La Princesa, 28006 - Madrid/ES
  • 10 Inmunology, Hospital Universitario de La Princesa, 28006 - Madrid/ES


Login to get immediate access to this content.

If you do not have an ESMO account, please create one for free.

Abstract 2548


Immunotherapy is a new and effective form of therapy in several types of cancer, although molecular predictors of response are limited. Recently, we have described that immune-related adverse-events (irAEs) are significantly associated with immunotherapy efficacy, and it has been suggested that body mass index (BMI) might be a favourable factor. We have studied whether excess weight influences the efficacy outcomes of immunotherapy and whether it is associated with immune-related adverse events. We have also evaluated the combined effect of overweight and irAEs.


We calculated BMI in patients treated with single-agent anti-PD-1 antibodies for advanced cancer. Efficacy of anti-PD-1 treatment was evaluated with both objective response (OR) rate, and progression-free survival (PFS), and toxicity with irAEs. We established the association between overweight and OR, PFS and irAEs.


One hundred and thirty-two patients were included in the study. Primary malignancies were lung cancer (n = 93), melanoma (n = 12), head and neck carcinoma (n = 9), renal carcinoma (n = 6), urothelial carcinoma (n = 4), Hodgkin’s lymphoma (n = 3), and other cancers (n = 5). Median BMI was 24.9 kg/m2, and 64 patients (48.4%) were excess weight (BMI≥25 kg/m2). An OR was achieved in 50 patients (38.0%), and median PFS was 6 months. IrAEs occurred in 44 patients (33.3%). OR was significantly higher in excess weight patients that in patients with BMI <25 kg/m2 (51.6% vs 25.0%) (Odds Ratio 3.45, CI 95% 1.58-7.55, p = 0.0009). PFS was also significantly improved in excess weight patients (7.25 months vs 4 months, HR 1.72, CI 95% 1.12–2.64, p = 0.01). IrAEs were not more frequent in excess weight patients (54.5% vs 43.2%, p = 0.21). When BMI and irAES were combined, we observed a clear prognostic trend in OR rate (87.5% in overweight patients with irAEs, in contrast with 6.2% in patients with normal BMI) (OR 161.0, CI 95% 1.58-7.55 p < 0.00001), and PFS (14 months vs 3 months) (HR 5.89, p < 0.0001).


Excess weight patients with advanced cancer that receive single-agent anti-PD-1 antibody therapy exhibit a significantly improved clinical outcome compared with patients with normal BMI. This association was especially marked when BMI and irAEs were considered combined.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Instituto Investigacion Sanitaria Princesa.


Has not received any funding.


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.