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Poster Discussion – Melanoma and other skin tumours

4298 - 3-year relapse-free survival (RFS), overall survival (OS) and long-term toxicity of (neo)adjuvant ipilimumab (IPI) + nivolumab (NIVO) in macroscopic stage III melanoma (OpACIN trial)

Date

28 Sep 2019

Session

Poster Discussion – Melanoma and other skin tumours

Presenters

Christian Blank

Citation

Annals of Oncology (2019) 30 (suppl_5): v533-v563. 10.1093/annonc/mdz255

Authors

C.U. Blank1, J.M. Versluis1, I.L.M. Reijers1, K. Sikorska2, W.J. van Houdt3, J.V. van Thienen1, S. Adriaansz1, H.A. Mallo4, H. van Tinteren2, B.A. van de Wiel5, L.G. Grijpink-Ongering2, A. Bruining6, J.B.A.G. Haanen1, A.C.J. van Akkooi3, T.N. Schumacher7, E.A. Rozeman1

Author affiliations

  • 1 Department Of Medical Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek (NKI-AVL), 1066 CX - Amsterdam/NL
  • 2 Department Of Biometrics, Netherlands Cancer Institute/Antoni van Leeuwenhoek (NKI-AVL), 1066 CX - Amsterdam/NL
  • 3 Department Of Surgical Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek (NKI-AVL), 1066 CX - Amsterdam/NL
  • 4 Department Of Medical Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek (NKI-AVL), 1066CX - Amsterdam/NL
  • 5 Department Of Pathology, Netherlands Cancer Institute/Antoni van Leeuwenhoek (NKI-AVL), 1066 CX - Amsterdam/NL
  • 6 Department Of Radiology, Netherlands Cancer Institute/Antoni van Leeuwenhoek (NKI-AVL), 1066 CX - Amsterdam/NL
  • 7 Department Of Molecular Oncology & Immunology, Netherlands Cancer Institute/Antoni van Leeuwenhoek (NKI-AVL), 1066 CX - Amsterdam/NL

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Abstract 4298

Background

Outcome of high-risk stage III melanoma patients (pts) was poor with a 5-year OS rate of < 50%. Adjuvant (adj) IPI improved 5-year RFS and OS and adjuvant anti-PD-1 improved RFS further. Preclinical data suggested that neoadjuvant (neoadj) treatment might be more favorable due to broader immune activation. The investigator-initiated OpACIN trial compared neoadj with adj IPI + NIVO. Neoadj IPI + NIVO induced a pathologic (path) response in a high percentage of pts (7/9 evaluable pts, 78%). None of the reponders relapsed during the first 2 years, but long-term outcome is pending. Here we present the 3-year landmark safety and survival data.

Methods

Between Augustus 2015 and October 2016, 20 stage IIIB/IIIC melanoma pts with palpable nodal disease were included in the phase Ib feasibility OpACIN trial. Pts were randomized to receive IPI 3 mg/kg + NIVO 1 mg/kg, either adj 4 courses or split 2 courses neoadj and 2 adj. Path response, as reviewed by a blinded pathologist, was defined as < 50% viable tumor cells. Landmark 3-year RFS and OS were estimated using Kaplan Meier method. All efficacy endpoints are descriptive since the study was not powered to compare both arms.

Results

After a median FU of 36.7 months (minimum 28.3 months FU of pts alive) none of the 7 pts with a path response in the neoadj arm have relapsed. Both non-responding pts in the neoadj have relapsed versus 4 pts in the adj arm. One pt has died in the neoadj arm and 3 in the adj arm. The estimated 3-year RFS rate was 80% for the neoadj arm and 60% for the adj arm. The 3-year OS rates were 90% and 67%, respectively. Of the 18 (90%) pts that had developed 1 or more grade 3-4 adverse events all have recovered to ≤ grade 1, except for grade 2 endocrine toxicities needing hormonal supplementation therapy that are ongoing in 8 (50%) of 16 pts alive.

Conclusions

OpACIN was the first trial investigating neoadj IPI + NIVO in pts with macroscopic stage III melanoma, thus having the longest FU. At 3 years FU, no new safety events occurred and none of the pts with a path response have relapsed, suggesting that path response could be considered as surrogate marker for RFS and OS in neoadjuvant checkpoint inhibitor trials.

Clinical trial identification

NCT02437279.

Editorial acknowledgement

Legal entity responsible for the study

Netherlands Cancer Institute.

Funding

BMS.

Disclosure

C.U. Blank: Advisory / Consultancy: MSD; Advisory / Consultancy, Research grant / Funding (institution): BMS; Advisory / Consultancy: Roche; Advisory / Consultancy: GSK; Advisory / Consultancy, Research grant / Funding (institution): Novartis; Advisory / Consultancy: Pfizer; Advisory / Consultancy: GenMab; Advisory / Consultancy: Lilly; Research grant / Funding (institution): NanoString; Advisory / Consultancy: Pierre Fabre. J.V. van Thienen: Advisory / Consultancy: Pfizer; Advisory / Consultancy: Novartis. J.B.A.G. Haanen: Advisory / Consultancy, Research grant / Funding (institution): BMS; Advisory / Consultancy, Research grant / Funding (institution): MSD; Advisory / Consultancy: Pfizer; Advisory / Consultancy: AZ/MedImmune; Advisory / Consultancy: Roche/Genentech; Advisory / Consultancy: Ipsen; Advisory / Consultancy: Bayer; Advisory / Consultancy: Immunocore; Advisory / Consultancy, Research grant / Funding (institution): Novartis; Advisory / Consultancy: Seattle Genetics; Advisory / Consultancy, Research grant / Funding (institution): Neon Therapeutics; Advisory / Consultancy: Celsius Therapautics; Advisory / Consultancy: Gadet; Advisory / Consultancy: GSK. A.C.J. van Akkooi: Advisory / Consultancy, Research grant / Funding (institution): Amgen; Advisory / Consultancy, Research grant / Funding (institution): BMS; Advisory / Consultancy, Research grant / Funding (institution): Novartis; Advisory / Consultancy: MSD Merck; Advisory / Consultancy: Merck-Pfizer; Advisory / Consultancy: 4SC. T.N. Schumacher: Advisory / Consultancy: Adaptive Biotechnologies; Advisory / Consultancy, Shareholder / Stockholder / Stock options: AIMM Therapeutics; Advisory / Consultancy, Shareholder / Stockholder / Stock options: Allogene Therapeutics; Advisory / Consultancy: Amgen; Advisory / Consultancy, Shareholder / Stockholder / Stock options: Merus; Advisory / Consultancy, Shareholder / Stockholder / Stock options: Neon Therapeutics; Advisory / Consultancy: Scenic Biotech; Research grant / Funding (institution): MSD; Research grant / Funding (institution): BMS; Research grant / Funding (institution): Merck KGaA; Shareholder / Stockholder / Stock options: Neogene Therapeutics; Shareholder / Stockholder / Stock options, Venture partner: Third Rock Venture. E.A. Rozeman: Travel / Accommodation / Expenses: MSD; Travel / Accommodation / Expenses: NanoString. All other authors have declared no conflicts of interest.

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