Abstract 46P
Background
It has been reported that the tumor microenvironment plays an important role in the development of breast cancer. Background parenchymal enhancement (BPE) on magnetic resonance imaging (MRI) has reportedly been associated with the risk of breast cancer development. Moderate or marked BPE has been associated with a higher risk of breast cancer development compared to minimal BPE. Furthermore, peritumoral edema on MRI has been reported to be associated with aggressive breast cancer and higher tumor recurrence rate. The purpose of our study was to evaluate the differences in genomic expression of breast cancers according to the imaging phenotype of adjacent parenchymal tissue such as background parenchymal enhancement and peritumoral edema on MRI.
Methods
This prospective study was reviewed and approved by our institutional review board and all patients provided written informed consent. We included 78 women who were newly diagnosed with breast cancer and underwent preoperative MRI at a single tertiary hospital from June 2020 to January 2023. According to the BIRADS lexicon, two radiologists interpreted background parenchymal enhancement and peritumoral edema on MRI. RNA sequencing was conducted with total RNA obtained from a surgical specimen by using next-generation sequencing.
Results
Breast cancers showing non-minimal (mild, moderate and marked) background parenchymal enhancement were associated with upregulation of KRT14 (log2FC = 1.83; P < .001), SFRP1 (log2FC = 1.47; P < .001), KRT17 (log2FC = 1.31; P = .005) and EFHD1 (log2FC = 1.21; P < .001). Breast cancers showing peritumoral edema on T2-weighted MR image were associated with upregulation of FDSCP (log2FC = 2.64; P < .001), CRABP1 (log2FC = 2.55; P < .001), LCN2 (log2FC = 2.29; P < .001), S100A9 (log2FC = 2.02; P = .004), GABRP (log2FC = 2.02; P < .001), CALML5 (log2FC = 2.01; P = .004) and downregulation of PIP (log2FC = -2.48; P = .009) and AZGP1 (log2FC = -2.18; P < .001).
Conclusions
Background parenchymal enhancement and peritumoral edema around the breast cancer reflected variable genomic alterations associated with stromal invasion, tumor aggressiveness and prognosis.
Legal entity responsible for the study
T. H. Kim.
Funding
National Research Foundation of Korea grant funded by the Republic of Korea government.
Disclosure
All authors have declared no conflicts of interest.