Abstract 249P
Background
Breast conservation surgery (BCS) is the preferred surgical treatment modality for eligible breast cancer patients. Oncological safety and aesthetic outcomes remain the primary objective of breast conservation surgery. Positive margin status following BCS needs revision surgery, which leads to increased patient anxiety, cost of treatment and delay in start of adjuvant treatment. We evaluated the significance and accuracy of intraoperative frozen section assessment of cavity shave margins (IOFSA) in patients undergoing BCS.
Methods
Prospectively maintained database of patients with breast cancer who underwent lumpectomy with IOFSA of cavity shave margins from June 2016- January 2022 in our department was analysed.
Results
A total of 116 patients had undergone IOFSA of cavity shave margins. The median age was 48 (Range 20-77) years. Patients belonged to the following clinical-stage group: Stage 0: 2 (2%), Stage I: 16 (14%) or Stage II: 91 (780%) and Stage III: 7 (6%) breast cancer. Ten patients (9%) underwent neoadjuvant chemotherapy. Out of 116 patients, a total of 98 patients (84%) underwent BCS, and the rest 18 patients (16%) underwent modified radical mastectomy (MRM). Twenty 20 (17%) patients had positive margins on IOFSA. Five false positives and two false negatives were detected for IOFSA on the final paraffin evaluation. The sensitivity of IOFSA was 88.2%, specificity 95% and accuracy of 94%. None of the patients required re-resection of the margin/second stage surgery.
Conclusions
IOFSA of cavity shave margins is a simple, effective and accurate technique to decrease second stage surgery, thereby improving the BCS rates.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.