Abstract 313P
Background
Quantitative analyses of miRNA are potential methods for the detection of carcinoma. Some studies have revealed the importance of microRNAs (miRNAs) function as biomarkers in diagnosing renal cell carcinoma. However, some results are discordant. This study is the first to systematically evaluate the accuracy of circulating miRNA for the diagnosis of renal cell carcinoma found in plasma, serum and urine by conducting meta-analysis.
Methods
We searched PubMed, Embase, Cochrane Library and Google Scholar databases systematically for relevant literatures up to January 10, 2020. The HSROC model was used to calculate the pooled diagnostic parameters and summary receiver operator characteristic (SROC) curve in this meta-analysis, thereby estimating the whole predictive performance. Meta-regression was performed to identify the sources of heterogeneity. All analyses were conducted using RevMan 5.3, MetaDTA, Metadisc Ver 3.0 and Medcalc Ver 19.
Results
This meta-analysis included a total of 18 studies in 12 researches, including 817 renal cell carcinoma patients and 622 healthy controls. The summary estimates for quantitative analysis of miRNA in renal cell carcinoma were as follows: sensitivity, 0.80 (95% confidence interval (CI), 0.75– 0.83); specificity, 0.69 (95% CI, 0.61–0.76); positive likelihood ratio, 2.6 (95% CI, 2.0– 3.2); negative likelihood ratio, 0.28 (95% CI, 0.22–0.34); diagnostic odds ratio, 9.2 (95% CI, 5.7–12.8); and area under the curve, 0.74 (95% CI, 0.70–0.78). Additionally, sub-group and meta-regression analyses revealed that there were no significant differences between ethnicity, year of publication, sample type and miRNA profiling. There was no statistical significance for the evaluation of publication bias.
Conclusions
Current evidence suggests that quantitative analysis of miRNA has acceptable sensitivity but unsatisfactory specificity for the diagnosis of renal cell carcinoma. Further large-scale prospective studies are required to validate the potential applicability of using miRNA alone or in combination with diagnostic test for renal cell carcinoma and explore potential factors that may influence the accuracy of renal cell carcinoma diagnosis.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Jestoni V. Aranilla MD.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.
Resources from the same session
285P - Comparison of induction chemotherapy plus concurrent chemoradiotherapy and concurrent chemoradiotherapy alone in locally advanced nasopharyngeal carcinoma: A meta-analysis
Presenter: Xu Guoqiang
Session: e-Poster Display Session
286P - Improved diagnostic accuracy on MR imaging in post-surgical recurrent head and neck SCC lesions using decision tree classification system
Presenter: Ankush Jajodia
Session: e-Poster Display Session
287P - Establishment of nasopharyngeal carcinoma organoid culture system and preliminary exploration of drug sensitivity test in vitro
Presenter: Wang Wen
Session: e-Poster Display Session
288P - Application of volumetric modulated arc therapy (VMAT) in head and neck cancers: 5-year single institutional experience
Presenter: Hiep Doan
Session: e-Poster Display Session
289P - Radiotherapy in advanced nasopharyngeal carcinoma
Presenter: Chih Kiang Tan
Session: e-Poster Display Session
292P - Shared decision-making at the cancer institute adult outpatient clinics of a tertiary hospital in the Philippines: A cross sectional study
Presenter: Marvin Jonne Mendoza
Session: e-Poster Display Session
293P - Prolonged release (PR) oxycodone/naloxone (OXN) for cancer pain (CP) & its impact on bowel function, safety & quality of life (QoL): Systematic review
Presenter: Sam Hjelmeland Ahmedzai
Session: e-Poster Display Session
294P - Interventional pain treatment in patients with pain syndrome in advanced tumours of small pelvis
Presenter: Yakhyo Ziyaev
Session: e-Poster Display Session
295P - Assessment of the impact of palliative care on the quality of life in advanced non-small cell lung cancer patients
Presenter: Sabin Katpattil
Session: e-Poster Display Session
296P - Outcomes of repeat transhepatic percutaneous biliary drainage in patients presenting with recurrent malignant biliary stricture
Presenter: Deevia Hanji
Session: e-Poster Display Session