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Proffered paper and Mini oral mixed session on Head and neck

269MO - Comparison of three induction chemotherapy regimens with gemcitabine plus cisplatin, cisplatin plus fluorouracil, and cisplatin plus capecitabine for locoregionally advanced nasopharyngeal carcinoma: A pooled analysis of two prospective studies

Date

21 Nov 2020

Session

Proffered paper and Mini oral mixed session on Head and neck

Presenters

Sik Kwan Chan

Citation

Annals of Oncology (2020) 31 (suppl_6): S1347-S1354. 10.1016/annonc/annonc360

Authors

S.K. Chan1, C.W. Choi1, S.Y. Chan1, C.C. Tong1, K.O. Lam1, D.L.W. Kwong1, T.W. Leung1, M.Y. Luk2, A.W.M. Lee1, V.H.F. Lee1

Author affiliations

  • 1 Clinical Oncology Department, The University of Hong Kong Li Ka Shing Faculty of Medicine, NA - Pokfulam/HK
  • 2 Department Of Clinical Oncology, Queen Mary Hospital, NA - Pokfulam/HK
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Resources

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Abstract 269MO

Background

We report the results of our prospective study comparing the differences in efficacy and safety between three induction chemotherapy regimens of gemcitabine plus cisplatin (GP), cisplatin plus fluorouracil (PF) and cisplatin plus capecitabine (PX) in previously untreated locoregionally advanced nasopharyngeal carcinoma (NPC).

Methods

Induction chemotherapy with either GP (from our prospective observational study), PF or PX (from NPC-0501 study) was given in prospectively recruited patients who had previously untreated locoregionally advanced (stage III to IVA) NPC. The primary study objectives included locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). The secondary objectives were major treatment-related toxicities (grade ≥ 3), both acute and late.

Results

From 2006 to 2016, 278 patients were enrolled (84, 94 and 100 patients in GP, PF and PX group respectively). After a median follow-up duration of 80 months, the 3-year LRFS, DMFS, PFS, CSS and OS of the whole population were 84.9%, 80.9%, 78.7%, 89.8% and 88.1% respectively. There were no statistically significant difference in pre-specified survival endpoints between GP, PF and PX group in both stage III and stage IVA patients. GP group had a lower incidence of severe (grade 3 or 4) anaemia and diarrhoea in stage III patients; and severe anaemia, dehydration, renal impairment and vomiting in stage IVA patients. The incidences of grade 3 or 4 late toxic effects were similar between 3 induction regimen groups.

Conclusions

GP had similar efficacy and potentially fewer complications as compared with PF and PX.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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