26P - Body mass index and clinical outcomes in Egyptian women with breast cancer: A multi-institutional study

Background

The aim of this work was to evaluate the association between body mass index (BMI) and clinical outcomes among Egyptian breast cancer patients.

Methods

We reviewed the file registry of 629 patients with operable breast cancer regarding age, sex, height, weight, family history of breast cancer, menopausal status, tumor characteristics, TNM classification, and treatment during the period from January 2006 to December 2012. In our analyses, obesity was defined as a BMI of ≥30 kg/m2. The primary objective was to estimate the effect of obesity on the clinical outcomes of breast cancer patients including DFS and OAS.

Results

A total of 629 patients with a mean age of 51.1 years. Stage III and Stage II presented 52% and 46.6% respectively. Overweight and obese patients represent 60.5% of all patient population. there was no association between tumor stage, grade or menopausal status and BMI. Patients with normal BMI showed a median survival of 95.3 months [ CI: 54.6,136.06]. This was significantly higher than overweight and obese patients (p = 0.001). Nearly one-third of patients (29.1%) with normal BMI experienced disease relapse compared to 32.8% for overweight and obese patients, however, this was statistically not significant (0.097).

Conclusions

According to the results of this retrospective study, Obesity is an independent prognostic factor for OS in patients with operable breast cancer.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Minia University Hospital and Mansura University Hospital.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.