Abstract 150P
Background
The status of PNI, a recognized immunonutritional marker, shows significant potential for forecasting oncological results. Textbook Outcomes (TOs) serve as thorough assessment tools for evaluating surgical outcomes. The connection between PNI, patient prognosis, and TOs in perihilar cholangiocarcinoma (pCCA) is still uncertain. This study seeks to assess the associations between PNI and TOs, as well as elucidate the status of lymphocyte infiltration at varying PNI levels in pCCA patients.
Methods
In this study, a retrospective study was conducted on 105 pCCA patients who underwent surgery with curative intent. Our examination focused on assessing the potential effects of PNI levels on patient oncological outcomes and Textbook Outcomes (TOs). Additionally, we aimed to analyze the relationship between PNI levels and the immune microenvironment.
Results
Patients with a high PNI showed a significantly extended overall survival (OS) compared to those with a lower PNI (24.7 months vs. 9.5 months, P=0.001). Multivariate analysis confirmed PNI (P=0.001) and TOs (P=0.044) as independent risk factors associated with OS. Further investigations revealed that patients with different PNI levels in pCCA displayed distinct immune microenvironments, with high PNI levels correlated with increased peritumoral CD3+ T cell and CD8+ T cell infiltration.
Conclusions
Patients with pCCA who have a high PNI demonstrate favorable oncological outcomes and a higher incidence of achieving TOs. Therefore, PNI could potentially be utilized as a valuable tool to help physicians predict patient prognosis and the likelihood of achieving TOs.
Clinical trial identification
SYSKY-2024-468-01.
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.