Abstract 779P
Background
Angiogenesis plays a role in cancer progression and metastasis. In Hodgkin lymphoma, micro-vessel density (MVD) has been widely used to estimate the degree of angiogenesis. The role of MVD in classical Hodgkin lymphoma is not well defined. The aim of this study is to review prognostic value of MVD in classical Hodgkin lymphoma.
Methods
We searched systematic in several databases for instance PubMed, Science Direct, Google Scholar, Cochrane with relevant keywords related to, classical Hodgkin lymphoma, micro-vessel density, and survival, progression free survival and overall survival. The observational studies last twenty years that reported the association between MVD and survival in classical Hodgkin lymphoma were included. The quality of included study was assessed using Newcastle Ottawa Scale tool.
Results
We included 10 studies with total 968 patients. Five studies were using CD31 as marker for MVD, while the other five were using CD34. There was 6 studies using overall survival as end point. Two studies (402 patients) concluded that MVD negatively correlated with overall survival (OS), while one study with 167 patients concluded that MVD negatively correlated in event free survival (EFS). Three other studies (236 patients) showed no significant correlation between MVD with OS, progression free survival (PFS), relapse and recurrent rate, or disease free survival (DFS). MVD was negatively correlated with stadium, and MVD was shown higher in relapsed refractory HL, however, no correlation between MVD with clinical and pathological profile.
Conclusions
There were conflicting results between studies. However, several studies shown microvascular density associated with worse survival in classical Hodgkin lymphoma. Further multi centre prospective study is needed to see a real association between MVD and survival parameter in classical Hodgkin lymphoma.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.