Abstract 102P
Background
The prognostic significance of primary tumor sidedness in colorectal cancer (CRC), classified as right-sided colon cancer (R-CRC) versus left-sided colon cancer (L-CRC), is well-established. Tumor location is linked to distinct molecular profiles, clinical outcomes, and treatment responses. Despite this, the impact of tumor sidedness on early-onset colorectal cancer (EOCRC) remains under-investigated, particularly within the Omani population.
Methods
We conducted a single-center retrospective cross-sectional study at Sultan Qaboos University Hospital, analyzing 321 CRC patients from 2008 to 2018. Data on demographics, tumor characteristics, treatment modalities, and survival outcomes were collected. The association between tumor sidedness and clinicopathological parameters, as well as survival rates, was evaluated, with a focus on comparing EOCRC with late-onset CRC (LOCRC).
Results
Of the 321 patients, 82 had R-CRC, and 239 had L-CRC. No significant gender association with tumor side was noted. While R-CRC showed a slight survival advantage in younger patients, this was not statistically significant. Similarly, there was no marked difference in survival between EOCRC and LOCRC when stratified by tumor stage. Stage IV patients had poorer survival outcomes, although this was not significantly different between EOCRC and LOCRC.
Conclusions
Primary tumor sidedness in CRC patients in Oman does not significantly affect survival outcomes between EOCRC and LOCRC, indicating that other factors may contribute to prognosis mainly the stage. This study stresses on the necessity for tailored, region-specific research to better understand the unique characteristics affecting CRC prognosis.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The author.
Funding
The project is funded by the deanship of research at Sultan Qaboos University.
Disclosure
The author has declared no conflicts of interest.