Abstract 304P
Background
Wilms tumour is the most common treatment responsive pediatric solid tumour. The outcome of Wilms tumour has improved due to the evolution of treatment approach. The purpose of this study was to analyse the clinical outcome of children with Wilms tumour treated by SIOP protocol in a regional cancer center.
Methods
In total 30 patients treated by SIOP protocol were analysed from a duration of June 2018 to June 2024.
Results
Gender distribution showed a male to female ratio of 6:1 with median age at diagnosis of 48 months with youngest being 7 months to oldest being 8 yrs . The abdominal lump was the dominant clinical presentation with a mean duration of 35 days (15 days to 2 months). Radiological staging work up showed that stages 1,2,3,4,5 were 23%,34%,13.3%, 40%,2 0%,3.3%, respectively. Neoadjuvant chemotherapy was received by all patients. In addition, 20% had metastasis at presentation, with lung as most common site and 46.4% of patients have high-risk histology. Disease relapse was seen in 20% of patients. Out of 24 alive patients 23 patients are without disease (15 months-69 months), one patient is alive with disease, and 6 patients died due to disease. The mean DFS and OS were 33.8 months (6months -69months) and 34.7 months (7 months -69 months), respectively.
Conclusions
The majority of patients presenting to our center are in advanced stage. Though the clinicopathological profile was more in line with western data,survival of patients with Wilms tumour is lower compared to high income countries due to delay in presentation and poor adherence to treatment.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
P. Kushala.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.