Abstract 602P
Background
This study aims to evaluate the efficacy and safety of low-power intermittent microwave ablation (MWA) in treating ground-glass nodules (GGOs) in early-stage lung cancer. It also seeks to compare the outcomes with those of high-power MWA, highlighting the potential benefits of a lower power approach in minimizing complications.
Methods
A retrospective analysis was conducted on 131 GGO cases treated with low-power intermittent MWA (40W) from January 2019 to December 2022. These results were compared with patients treated with high-power MWA (>60W) during the same period. The effectiveness of MWA was assessed by evaluating changes in lesion size and absorption rates post-procedure. Additionally, postoperative complications were systematically recorded and analyzed to compare the safety profiles of the two approaches.
Results
The success rate of nodule ablation with low-power MWA was 100%, with NADH staining confirming complete cell death in the target area. Lesion size significantly reduced 24 hours post-procedure (p<0.001), with an overall absorption rate of 80.2% at three months. In contrast, high-power MWA, although effective, had a higher complication rate, including large pneumothorax (11.4%) and excessive lung tissue damage. Complications from low-power MWA were milder and more manageable, with minor pneumothorax (58.0%) and pleural indentation (39.7%) being the main issues.
Conclusions
The study concludes that low-power intermittent MWA at 40W is highly effective and safe for eliminating GGO nodules, offering significant advantages in terms of fewer complications and better patient tolerance compared to high-power MWA. Low-power intermittent MWA emerges as a safe and effective treatment option for early-stage lung cancer patients, providing a favorable balance between efficacy and safety.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The author.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.