Abstract 16P
Background
This study aimed to assess preferences of patients and healthcare practitioners (HCPs) regarding treatment attributes for early-stage triple-negative breast cancer (TNBC) in the Asia-Pacific region.
Methods
A discrete choice experiment (DCE) was conducted in Australia, Korea, Philippines, Japan, and Taiwan, with 115 patients who self-reported a diagnosis of early-stage TNBC and 86 HCPs. Key attributes relevant to TNBC treatment decision-making were verified through qualitative interviews with clinical experts. A D-efficient fractional-factorial design was employed to create 15 online choice sets with seven key attributes: disease-free/event-free survival (DFS/EFS), pathological complete response (pCR), chance of undergoing breast conserving surgery after receiving anticancer treatment, febrile neutropenia, peripheral sensory neuropathy, diarrhea, and irreversible endocrine-related adverse events (AEs) requiring lifelong medication. A mixed logit model was used to estimate preference weights for attribute levels, which were then used to compute the relative importance score (RIS) for each attribute.
Results
Median age of patients were 44.0 (interquartile range 38.0-56.5) years. 68% of patients were married, 77% had children, 40% employed full-time and 70% had a college degree. 46% of patients were diagnosed below the age of 40. Among the HCPs, 58% were medical oncologists and the remaining breast or general surgeons. PCR, DFS/EFS, and peripheral sensory neuropathy were the three most important attributes in both HCP and patient groups. pCR had the highest weighted preference among patients and HCPs (RIS, 28.46 and 32.86, respectively). In general, patients assigned greater weight to safety attributes compared to HCPs, while HCPs assigned more weight to efficacy attributes than patients. Surgeons assigned more weight for irreversible endocrine-related AEs than medical oncologists (RIS, 14.4 vs. 5.4).
Conclusions
Overall, patients and HCP preferences were aligned in ranking for efficacy and safety attributes tested. Differences in preferences within the regions were notable.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
IQVIA Solutions Asia Pte. Ltd.
Funding
MSD International GmbH, Singapore Branch.
Disclosure
J. Lai, Y. Antill, K.H. Jung, C. Shimizu, M.L. Abesamis Tiambeng: Financial Interests, Personal, Advisory Board: MSD. E.M. Tan, S. Qu: Financial Interests, Personal, Full or part-time Employment, IQVIA was commissioned to carry out this study.: IQVIA Asia Pacific. C. Spiteri, S.Y. Ihm, D. Hsu: Financial Interests, Personal, Full or part-time Employment: MSD. All other authors have declared no conflicts of interest.
Resources from the same session
373P - Investigating the impact of treatment on geriatric patients with locally advanced head and neck squamous cell carcinoma
Presenter: Yen Ting Liu
Session: Poster Display
Resources:
Abstract
374P - Immunohistochemical evaluation of oral lichen planus: A prospective clinical study
Presenter: Saravanan Sampoornam Pape
Session: Poster Display
Resources:
Abstract
375P - Survival and prognostic factors of head and neck squamous cell carcinoma patients treated with either definitive CCRT or post operative CCRT with platinum-based chemotherapy in Rajavithi hospital, Thailand
Presenter: wanit samadee
Session: Poster Display
Resources:
Abstract
376P - Nutrition as an independent prognostic factor in locally advanced nasopharyngeal carcinoma: A retrospective cohort study and propensity score-matched analysis
Presenter: haizhen yi
Session: Poster Display
Resources:
Abstract
377P - Oropharyngeal squamous cell carcinomas in Indian population: P16 positivity and treatment outcomes following chemoradiotherapy
Presenter: Parth Verma
Session: Poster Display
Resources:
Abstract
378P - A real-world retrospective analysis of the efficacy of pembrolizumab combined with chemotherapy as neoadjuvant treatment for locally advanced head and neck squamous cell carcinoma (LA HNSCC)
Presenter: zhu Liu
Session: Poster Display
Resources:
Abstract
379P - Nimotuzumab in combination with chemoradiation for patients with intermediate stage and locally advanced nasopharyngeal carcinoma: A retrospective comparative analysis using 5-year real-world survival data
Presenter: Andhika Rachman
Session: Poster Display
Resources:
Abstract
380P - An epidemiological analysis on the prevalence of oral cancer and its awareness among Irula tribes of South India
Presenter: Delfin Lovelina Francis
Session: Poster Display
Resources:
Abstract
381P - P16INK4 over-expression, early stages, keratinization, and surgical margin-free status are associated with better prognosis of oral squamous cell carcinoma (OSCC)
Presenter: Sumadi Lukman Anwar
Session: Poster Display
Resources:
Abstract
382P - Oral health disparities in privileged and underprivileged tribes of south India: A study of the prevalence of precancerous oral lesions
Presenter: Shanavas Palliyal
Session: Poster Display
Resources:
Abstract