Abstract 570P
Background
Osimertinib is the standard of care for the first-line treatment of advanced NSCLC (aNSCLC) patients (pts) with epidermal growth factor receptor (EGFR) activating mutations. Limited Chinese patients’ data in real-world setting are available regarding the effectiveness of osimertinib in EGFRm aNSCLC, especially in patients harboring uncommon EGFR mutations.
Methods
Patients treated with first-line osimertinib were retrospectively collected from 11 hospitals in China between March 25, 2017 and December 31, 2022. Mutations were categorized as EGFR activating mutations (19del/21L858R; cohort 1) and uncommon mutations (G719X, L861Q, S768I, 20ins, de novo T790M; cohort 2). Patient characteristics, progression-free survival (PFS), time to progression (TTP), objective response rate (ORR), and disease control rate (DCR) were analyzed.
Results
A total of 385 patients with stage IV NSCLC were included, 308 pts in cohort 1 and 77 pts in cohort 2. The median age was 59 years, 214 (55.6%) were female, 350 (90.9%) were adenocarcinoma, and 141 (36.6%) patients had documented brain metastases (35 patients received whole-brain radiotherapy). In cohort 1, the median follow-up was 32.8 months and mPFS was 20.8 months (19del subgroup: 22.7 months; 21L858R subgroup: 14.8 months). For patients with/without documented brain metastases, mPFS was 15.6 months and 23.4 months, respectively. mTTP was 21.5 months for all patients. ORR was 75.6%, including 3 patients with CR and 230 patients with PR. DCR was 94.2%. In cohort 2, ORR was 64.9% (50 patients with SD) and DCR was 93.5%. with a median follow-up of 8.3 months, both mPFS and mTTP were 7.3 months. No new safety signals were observed. Table: 570P
| Cohort 1 (19del, 21L858R) | Cohort 2 (G719X, L861Q, S768I, 20ins, de novo T790M) | |
| n (%) | 308 (80%) | 77 (20%) |
| CRPRSDPD | 3 (0.9%)230 (74.7%)57 (18.5%)18 (5.9%) | 0 (0%)50 (64.9%)22 (28.6%)5 (6.5%) |
| ORR (%) | 75.6% | 64.9% |
| DCR (%) | 94.2% | 93.5% |
| mPFS (month) | 20.8m | 7.3m |
| mTTP(month) | 21.5m | 7.3m |
Conclusions
The result is consistent with FLAURA study for patients with EGFR-activating mutation. Osimeritinib showed clinical activity in patients with EGFR uncommon mutations as first-line treatment.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
496P - Fruquintinib plus sintilimab in patients (pts) with advanced non-small cell lung cancer (NSCLC) with PD-L1-positive expression: A multicenter, single-arm phase II study
Presenter: Shun Lu
Session: Poster Display
Resources:
Abstract
497P - Sintilimab in combination with anlotinib in advanced NSCLC treated with first-line PD-1 antibodies: An open, single-arm, phase II trial
Presenter: Ying Jin
Session: Poster Display
Resources:
Abstract
498P - Frailty-adjusted life expectancy and survival in older lung cancer patients: A large-scale electronic health-record based study
Presenter: Thao Tu
Session: Poster Display
Resources:
Abstract
499P - Long-term survival and treatment (tx) patterns after first-line (1L) osimertinib in patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive (m) advanced non-small cell lung cancer (NSCLC): Japanese cohort of a global real-world (rw) observational study
Presenter: Daichi Fujimoto
Session: Poster Display
Resources:
Abstract
500P - The effectiveness and safety of durvalumab after chemoradiotherapy for locoregional recurrence of completely resected non-small cell lung cancer: Real-world, multicenter, observational study (NEJ056)
Presenter: Hidehito Horinouchi
Session: Poster Display
Resources:
Abstract
501P - One-year survival outcomes of unresectable stage III non-small cell lung cancer patients who underwent PD-1 inhibitor plus chemo as induction therapy
Presenter: Xin Wang
Session: Poster Display
Resources:
Abstract
502P - Impact of sarcopenia on the outcome of patients with locally advanced non-small cell lung cancer treated with chemoradiotherapy followed by durvalumab
Presenter: Kentaro Tamura
Session: Poster Display
Resources:
Abstract
503P - Clinical outcomes by infusion timing of immune checkpoint inhibitors in patients with locally advanced NSCLC
Presenter: TSUYOSHI HIRATA
Session: Poster Display
Resources:
Abstract
504P - Real-world outcomes with induction systemic therapy for stage III in eligible for upfront local therapy: Pre vs post immunotherapy era in a tertiary referral centre
Presenter: Praveen Kumar Marimuthu
Session: Poster Display
Resources:
Abstract
505P - Neoadjuvant PD-1 inhibitor (tislelizumab) plus platinum–etoposide in patients with limited-stage small cell lung cancer: A phase II trial
Presenter: Junjie Hu
Session: Poster Display
Resources:
Abstract