Abstract 549P
Background
Interstitial pneumonia (IP) or interstitial lung abnormalities (ILA) is a risk factor for drug-induced interstitial lung disease (D-ILD) in immunotherapy. We usually evaluate interstitial pneumonia by CT findings without histopathological findings. We aimed to evaluate whether histopathological findings of the background lung in surgical specimens is correlated with development of D-ILD by immunotherapy in patients with postoperative recurrence.
Methods
Patients who were treated with immunotherapy or immunochemotherapy for first-line treatment of non-small cell lung cancer for postoperative recurrence from April 2017 to February 2023 were included. We retrospectively compared between characteristics of patients with and without D-ILD, including CT findings and histopathological findings of the background lung in surgical specimens.
Results
Among 32 included patients, we evaluated 27 patients whose surgical specimens were available. The median age was 72 years old, and 20 patients (74.1%) were male. Twelve patients (44.4%) had ILA on CT, and five patients (18.5%) had IP with usual interstitial pneumonia (UIP) pattern (two patients with UIP, one patient with probable UIP, and two patients with indeterminate for UIP) on pathology. Five patients (18.5%) developed D-ILD, including two patients with CTCAE grade 1, two patients with grade 2, and one patient with grade 5. Patients with D-ILD were significantly more likely to have ILA on CT than those without D-ILD (5/5[100%] vs. 7/22[31.8%], p<0.01). Although there was no significant difference, two of the patients with D-ILD had UIP pattern on pathology as compared with three of those without D-ILD (2/5[40%] vs. 3/22[13.6%] p=0.22). Four patients had both ILA on CT and UIP pattern on pathology, and two (50%) of these cases developed D-ILD.
Conclusions
In addition to chest CT findings, histopathological findings of the background lung in surgical specimens may be useful as predictors of D-ILD in immunotherapy.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
T. Tanaka: Financial Interests, Personal, Speaker, Consultant, Advisor: Boehringer Ingelheim GmbH, Mitsubishi Tanabe Pharma Corporation, Daiichi Sankyo; Financial Interests, Personal, Royalties: Bunkodo Co., Ltd., Gakken Inc. N. Katsurada: Financial Interests, Personal, Speaker, Consultant, Advisor: Bristol Myers Squibb Co., Ltd., Chugai Pharmaceutical Co., Ltd., MSD K.K. T. Nagano: Financial Interests, Personal, Invited Speaker: AstraZeneca K.K. M. Yamamoto: Financial Interests, Personal, Speaker, Consultant, Advisor: Chugai Pharmaceutical Co., Ltd. Chugai Pharmaceutical Co., Ltd., Chugai Pharmaceutical Co., Ltd., AstraZeneca K.K., Eli Lilly Japan K.K., Daiichi Sankyo, Taiho Pharmaceutical Co., Ltd. M. Tachihara: Financial Interests, Personal, Invited Speaker: Eli Lilly Japan K.K., Chugai Pharmaceutical Co., Ltd, AstraZeneca K.K, MSD K.K., Ono Pharmaceutical Co., Ltd., Bristol Myers Squibb Co. Ltd., Nippon Boehringer Ingelheim Co., Ltd., Pfizer Japan Inc., Daiichi Sankyo, Janssen Pharmaceutical K.K.; Financial Interests, Institutional, Research Grant: AstraZeneca K.K., Eli Lilly Japan K.K., Chugai Pharmaceutical Co., Ltd. All other authors have declared no conflicts of interest.
Resources from the same session
592P - Treatment patterns and outcomes in patients with advanced non-small cell lung cancer with MET exon 14 skipping alterations in China
Presenter: Hanxiao Chen
Session: Poster Display
Resources:
Abstract
593P - MET TKIs in Asian patients (pts) with MET exon 14 skipping NSCLC: A matching-adjusted indirect comparison (MAIC)
Presenter: E-e Ke
Session: Poster Display
Resources:
Abstract
594P - The treatment pattern and clinical outcome in NSCLC patients with MET alteration: A retrospective real-world analysis in China
Presenter: Yongfeng Yu
Session: Poster Display
Resources:
Abstract
595P - Durable efficacy of zenocutuzumab, a HER2 x HER3 bispecific antibody, in advanced NRG1 fusion-positive (NRG1+) non-small cell lung cancer (NSCLC)
Presenter: Koichi Goto
Session: Poster Display
Resources:
Abstract
596P - Repotrectinib in patients (pts) from Asia and China with ROS1 fusion-positive (ROS1+) non-small cell lung cancer (NSCLC): Results from the phase I/II TRIDENT-1 trial
Presenter: Ross Soo
Session: Poster Display
Resources:
Abstract
597TiP - A phase I/II study to evaluate the safety and anti-tumor activity of JIN-A02 in patients with EGFR TKI-refractory, EGFR-mutant advanced NSCLC
Presenter: Sun Min Lim
Session: Poster Display
Resources:
Abstract
598TiP - Exploration of aumolertinib in first-line treatment for advanced non-small cell lung cancer patients of performance status 3 with EGFR mutations (19del and L858R)
Presenter: Haiyi Deng
Session: Poster Display
Resources:
Abstract
599TiP - A prospective study of savolitinib plus docetaxel in pretreated EGFR/ALK/ROS1/METex14m-wildtype advanced NSCLC patients with MET overexpression (FirstMET)
Presenter: Shuting Zhan
Session: Poster Display
Resources:
Abstract
600TiP - Phase III study of telisotuzumab vedotin (Teliso-V) vs docetaxel in pretreated c-Met overexpressing EGFR wildtype (WT) non-squamous (NSQ) locally advanced/metastatic non-small cell lung cancer (a/mNSCLC)
Presenter: Junko Tanizaki
Session: Poster Display
Resources:
Abstract
601P - Pembrolizumab in patients of Chinese descent with microsatellite instability-high/mismatch repair deficient advanced solid tumors: KEYNOTE-158
Presenter: Xiaohua Wu
Session: Poster Display
Resources:
Abstract