Abstract 196P
Background
We sought to explore whether the circulating proliferative T lymphocyte subtypes in patients with advanced gastric cancer (AGC) can be used as an indicator of prognosis.
Methods
Blood samples were collected from patients with AGC before treatment and analyzed by fluorescence-activated cell sorting analysis. Patients were divided into two groups based on the ratio of CD8+ T cells to CD4+ T cells and the ratio of CD8+ T cells to CD4+ T cells within Ki-67+ T cells. Survival between the groups was compared using the Kaplan-Meier method and the log-rank test. Multivariate analyses were also performed.
Results
A total of 92 patients enrolled in the study. The median age was 64.2 years, and the male-to-female ratio was 2.3:1. The median survival duration was 12.5 months. No significant differences in progression-free survival (PFS) and overall survival (OS) were observed between the groups with high and low CD8/CD4 ratios. However, the group with a high ratio of CD8/CD4 within proliferating T cells (n = 46) had a significantly longer OS (16.8 months vs. 11.3 months; p = 0.011) compared to the group with a low ratio of CD8/CD4 within proliferating T cells (n = 46). PFS did not vary between these proliferating CD8/CD4 ratio groups. A multivariate analysis indicated that the ratio of proliferating CD8 to CD4 was an independent prognostic factor for OS.
Conclusions
A high CD8/CD4 ratio among proliferating T cells in circulation could be associated with a better prognosis in patients with AGC receiving first-line chemotherapy.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
540P - Phase III study of serplulimab plus chemotherapy as first-line therapy for advanced squamous non-small cell lung cancer: ASTRUM-004 Asian subgroup
Presenter: Caicun Zhou
Session: Poster Display
Resources:
Abstract
541P - Integrated analysis of randomized controlled trials IMpower130 and IMpower132 for advanced non-squamous non-small cell lung cancer (NSCLC)
Presenter: Hibiki Udagawa
Session: Poster Display
Resources:
Abstract
542P - First-line HLX07 plus serplulimab with or without chemotherapy versus serplulimab plus chemotherapy in advanced/recurrent squamous non-small cell lung cancer: A phase II study
Presenter: Zhen Wang
Session: Poster Display
Resources:
Abstract
543P - A multicenter retrospective study to investigate risk factors for immune checkpoint inhibitor-induced pneumonitis in non-small cell lung cancer patients with comorbid interstitial pneumonia
Presenter: Yuriko Ishida
Session: Poster Display
Resources:
Abstract
544P - Single cell level investigation of blood cells representing immune checkpoint inhibitor response in lung adenocarcinoma patients
Presenter: Juyong Seong
Session: Poster Display
Resources:
Abstract
545P - Completion of pembrolizumab in advanced non-small cell lung cancer: Real-world outcomes after two years of therapy (COPILOT)
Presenter: Andrew Fantoni
Session: Poster Display
Resources:
Abstract
546P - Combination therapy with anti-PD-1 antibody plus angiokinase inhibitor exerts synergistic antitumor effect against malignant mesothelioma via tumor microenvironment modulation
Presenter: Akio Tada
Session: Poster Display
Resources:
Abstract
547P - Immunotherapy outcome in advanced/metastatic lung cancer patients in real-world experience: Indian data
Presenter: Naveen K
Session: Poster Display
Resources:
Abstract
548P - B-Myb acts as a mentor instant promoter in non-small cell lung cancer by modifying the PD-1/PD-L1 axis
Presenter: Pan Xu
Session: Poster Display
Resources:
Abstract
549P - Drug-induced interstitial lung disease in patients with non-small cell lung cancer treated with immunotherapy for postoperative recurrence: Evaluation of CT findings and histopathological findings of the background lung
Presenter: shodai fujimoto
Session: Poster Display
Resources:
Abstract