183MO - Retreatment with platinum-based chemotherapy for recurrent endometrial cancer: The concept of platinum sensitivity in endometrial cancer

Background

Patients with endometrial cancer frequently receive adjuvant paclitaxel and carboplatin chemotherapies. Currently, there is no standard second-line chemotherapy for treating disease recurrence. It has been suggested that patients with endometrial cancer whose disease relapses more than 12 months after first-line platinum-based chemotherapy may benefit from retreatment.

Methods

We performed a retrospective analysis of patients retreated with second-line platinum-based chemotherapy for recurrent endometrial cancer between 2012 and 2020. Medical records, including all clinical and pathological parameters and details of chemotherapy administered, were reviewed. Response rate, median progression-free survival (PFS), and overall survival (OS) were estimated.

Results

In total, 135 patients were included in the analysis. We analyzed clinical outcomes according to the progression-free interval (PFI) from previous platinum-based chemotherapy. The response rates to retreatment with platinum-based chemotherapy were 24%, 33%, 67%, and 55% in patients with PFI was less than 6, 6–12, 12–24, and > 24 months, respectively. Median PFS increased with PFI as well, 4.8 months, 7.1 months, 10.0 months, and 16.9 months, for each group respectively. Median OS was 11.1 months, 13.6 months, 22.3 months, and 76.9 months, respectively.

Conclusions

These results suggest that patients with recurrent endometrial cancer who experience recurrence more than 12 months after the completion of initial platinum-based chemotherapy may benefit from retreatment with platinum-based chemotherapy, suggesting that the concept of platinum sensitivity may be applied to endometrial cancer.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.