Abstract YO8
Case summary
According to Globocan 2020, ovarian cancer (OC) is the eighth most common cancer in women and one of the leading causes of death from gynecological cancer. Five-year survival rates in patients with ovarian cancer are low, less than 45%. In 2020, 313,959 new cases of OC were registered, 70% of which are registered at an advanced stage. In Kazakhstan, malignant neoplasms of the ovaries occupy the 8th ranking position among malignant tumors. Despite the improvement in approaches to the diagnosis and treatment of OC, a high level of neglected cases and low 5-year survival rates in OC patients remain.
Since 2019 HIPEC has been performed in KazIOR for patients with ovarian cancer. From 2019 to 2021, 14 operations were performed, 7 (50%) of them in the volume of optimal cytoreduction, 7 (50%) operations in the volume of non-optimal cytoreduction, all operations were performed by abdominal access. 12 (85%) patients with stage 3c, 1 (7%) patient with stage 3b, 1 (7%) with stage 4a. Indications for HIPEC were: index of peritoneal carcinomatosis (PCI) less than 15, absence of severe concomitant diseases, verified ovarian cancer, histological forms: serous, mucinous carcinoma.
11 (78%) patients with primary ovarian cancer were operated on with HIPEC after 3-4 courses of NAPCT according to the PP scheme, 3 (21%) patients with recurrent cancer after combined treatment (chemo + surgery).
11 (78%) patients with a histological conclusion of serous carcinoma, 3 (21%) patients with mucinous adenocarcinoma.
Concomitant diseases were in 10 (71%) patients of them: type 2 diabetes mellitus in 2 (14%) patients, arterial hypertension in 5 (35%) patients, chronic pyelonephritis in 3 (21%) patients, bronchial asthma in 1 (7 %) of the patient, chronic bronchitis in 1 (7%) patient, chronic cholecystitis in 1 (7%) patient, moderate anemia in 1 (7%) patient.
In 2 (14%) patients, a complication after HIPEC in the form of acute renal failure was noted, 2 (14%) patients died from the progression of oncological disease.
Considering the data for a two-year study, it can be argued that intra-abdominal hyperthermic chemotherapy is a safe treatment option for patients with ovarian cancer. Evaluation of effectiveness, overall and disease-free survival will be carried out after 5 years.
Clinical trial identification
Editorial acknowledgement
Resources from the same session
YO1 - Locally Advanced Breast Cancer Outcome During Second Trimester of Pregnancy
Presenter: Jesilyn Palec
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Abstract
Slides
Webcast
YO9 - Primary refractoriness of recurrent ovarian clear cell carcinoma to anti–PD-1 inhibitor-based therapy in a patient with Lynch syndrome: Never take for granted
Presenter: Jack Chan
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Abstract
Slides
Webcast
Invited Discussant YO1, YO8 and YO9
Presenter: Matteo Lambertini
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Slides
Webcast
YO21 - A Rare Case of Pancreatic Metastasis from Primary Lung Adenocarcinoma. A Non Surgical Approach
Presenter: Aqueel Shahid
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Abstract
Slides
YO22 - Durable complete response to Alectinib in a second line setting in metastatic ALK+ve NSCLC patient with poor PS with initial NG tube administration
Presenter: Nitin Murthy
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Abstract
Slides
Webcast
Invited Discussant YO21 and YO22
Presenter: Teresa Amaral
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Slides
Webcast
Q&A and discussion
Presenter: Teresa Amaral
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Webcast
YO6 - Challenging case study of a transgender prostate cancer patient
Presenter: Khobe Chandran
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Abstract
Slides
Webcast
YO14 - Parotid Gland Salivary Duct Adenocarcinoma: New targets for new times
Presenter: Clara Garcia Gonzalez
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Abstract
Slides
Webcast
YO27 - Drastic response to cetuximab in metastatic eccrine porocarcinoma with EGFR amplification
Presenter: Katsushi Takaori
Session: Unusual challenges in clinical oncology: YO case discussions
Resources:
Abstract
Slides
Webcast