Abstract 56P
Background
The incidence of colorectal cancer (CRC) has increased among the younger population. Adolescents and young adults (AYA) are an important component of the active population in any country that impact the health care system along with socio-economic consequences. We present one of the first multicentre collaborative studies on AYA CRC from a low and middle-income country (LMIC).
Methods
The study was a multicentre retrospective registry conducted over the period of 3 years, from January 2018 to December 2020, after approval from respective IECs. A total of 126 AYA CRC Patients were enrolled in the study. The details regarding socio-demographic profile, histopathology, and therapeutic details were recorded.
Results
A total of 126 patients of AYA colorectal cancer patients were enrolled in the study between 2018 - 2020. 62.70% of patients had colon cancer, 37.30 % had rectal cancer. 50.79 % of patients were male. 67.46% of patients belong to 31-40 age group, with an average age of 32.6 years. Abdomen pain and distension (34%), and blood in stools (22%) were the most common presentations. On presentation, 31.75% had cTNM stage IV, 28.57% stage III, 15.87% stage II as per AJCC 8. 92(74.60%) underwent surgery, and adenocarcinoma (65.08 %) was the most common histology. 28.57% of patients were stage III on pTNM. Most of the patients were offered potentially curative therapy (65.87%), and 33.33% of patients were on palliative treatment. CAPOX was the most commonly prescribed chemotherapy regimen. MSI profiling was available only for eight patients.
Conclusions
As per our knowledge, this study is one of the first multicentre collaborative studies from an LMIC related to the clinic-pathological profile of AYA CRC patients. Most such patients present in non-metastatic stage, and potentially receive curative therapy. However, only a small minority could get MSI/mutational profiling.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Biotechnology Industry Research Assistance Council (BIRAC) India.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
119P - Clinicopathological features and roles of lymph node metastases in gastric cancer: A single-center retrospective study in China
Presenter: yuming zhang
Session: Poster viewing 02
120P - Clinical implication of DNA damage response gene in advanced gastric cancer stage IV and recurrent gastric cancer patients after gastrectomy treated palliative chemotherapy
Presenter: In Gyu Hwang
Session: Poster viewing 02
121P - Treatment patterns and outcomes of recurrent/metastatic esophageal cancer: Real-world data
Presenter: Amrith B P
Session: Poster viewing 02
122P - Efficacy and safety of mFOLFOX-6 in advanced gastric cancer: A prospective observational study
Presenter: Amrith B P
Session: Poster viewing 02
123P - Sarcomatoid carcinoma of gall bladder: A series of 14 cases from a single tertiary-care oncology centre
Presenter: Subhash Yadav
Session: Poster viewing 02
124P - Clinical profile and treatment outcomes of hepatocellular carcinoma from a tertiary care hospital in South India: A retrospective study
Presenter: Gayathri Nair
Session: Poster viewing 02
125P - A parametric network meta-analysis of PD-1 inhibitors in second-line treatment for advanced esophageal squamous cell carcinoma
Presenter: Shubhram Pandey
Session: Poster viewing 02
126P - Late line FOLFOX therapy after prior cisplatin-based regimen in advanced esophageal squamous cell carcinoma: A multi-institutional retrospective study
Presenter: Keitaro Shimozaki
Session: Poster viewing 02
127P - LABS score: The prognostic tool for advanced hepatocellular carcinoma treated with FOLFOX4 and real-world efficacy from a single-center retrospective study
Presenter: Jirapat Wonglhow
Session: Poster viewing 02
128P - Survival outcome of gastric cancer patients in a tertiary care center: A 10-year single center retrospective study
Presenter: Dawn Lynn Guardiario
Session: Poster viewing 02