Abstract 289P
Background
Cancer cachexia has been rarely reported in Indonesian BC patients. We aimed to determine the prevalence and factors associated with cancer cachexia following chemotherapy.
Methods
We performed a pre-post observation in 103 BC patients who received chemotherapy and were registered in a prospective study on chemotherapy toxicities in 2018-2020. Most data were abstracted from the main study database, including age, neutrophil-to-lymphocyte ratio, comorbidity, stage, surgery type, chemotherapy information, and the presence of chemotherapy-induced nausea and vomitus. We also analysed vitamin D concentration using ELISA method. Cachexia was defined according to existing criteria from Evans as weight loss of at least 5% or low BMI <20 kg/m2 plus low muscle strength, fatigue, anorexia, low fat-free mass index, or abnormal biochemistry. Multivariate logistic regression test was used to determine factors related to cachexia status following chemotherapy.
Results
Mean age of 103 patients was 52 years (52.5 ± 9.1). All patients had a deficient vitamin D concentration at baseline (median 8.4 ng/mL) and after chemotherapy (median 6.9 ng/mL). At baseline 4.9% of patients (5/103) had cachexia. After chemotherapy 28.2% of patients (29/103) had persistent cachexia or evolved into cachexia. Having persistent cachexia or becoming cachexia was significantly associated with late-stage presentation (OR 3.43, 95%CI 1.10–10.74, p=0.034), receiving >8 chemotherapy cycles (OR 12.05, 95%CI 2.29–63.46, p=0.003) and higher post-chemotherapy vitamin D level (OR 4.60, 95%CI 1.56–13.56, p=0.006). Having a higher baseline vitamin D level was significantly associated with a lower risk of persistent cachexia or evolving into cachexia after chemotherapy (OR 0.33, 95%CI 0.11–0.95, p=0.040).
Conclusions
Cachexia often occurs in local BC patients. Late-stage presentation, receiving >8 chemotherapy cycles and higher post-chemotherapy vitamin D level are associated with an increased risk of cachexia while having a higher baseline vitamin D level is associated with a reduced risk. Strategies and further investigation are warranted to improve cachexia with nutritional support during chemotherapy.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Kementrian Riset, Tekhnologi, dan Pendidikan Tinggi Republik Indonesia.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
281P - Cancer-related symptoms as mediators between treatment and functional capacity in adolescents and young adults (AYAs) with cancer
Presenter: Chung Tin Justin Ma
Session: Poster viewing 04
282P - Nutritional status and nutritional therapy of common cancer in a cancer hospital of Southwest China
Presenter: Huiqing Yu
Session: Poster viewing 04
283P - Comparative analysis of osteoporotic fracture (OF) and pathologic fracture (PF) in patients with metastatic colorectal cancer (mCRC) who received palliative chemotherapy
Presenter: Yejee Lim
Session: Poster viewing 04
284P - Gut microbiota mediates the protective effects of resveratrol against the intestinal barrier dysfunction in non-alcoholic steatohepatitis induced by high-fat diet
Presenter: Haoyang Cao
Session: Poster viewing 04
285P - Reticulocyte hemoglobin equivalent as an early predictor of iron deficiency anemia in cancer patients
Presenter: Aditya Sarin
Session: Poster viewing 04
286P - Breakthrough COVID-19 infections in patients with cancer from a prospective study of COVID-19 vaccine response
Presenter: Amy Body
Session: Poster viewing 04
287P - Long-term yoga enhances the quality of life and symptomatic scale in breast cancer patients undergoing treatment
Presenter: Mayank Jain
Session: Poster viewing 04
288P - Impact of hormonal contraception on estradiol and progesterone serum levels: A 6-year study on progression-free survival, disease-free survival, and overall survival at Dr. Moewardi Hospital
Presenter: Widyanti Soewoto
Session: Poster viewing 04
290P - Use of PEG G-CSF is associated with decreased myelotoxicity in dexrazoxane-used aggressive non-Hodgkin lymphoma patients
Presenter: Sung-Nam Lim
Session: Poster viewing 04
291P - Assessment of nutritional status in cancer patients using patient generated subjective global assessment screening tool
Presenter: Anuj K. C.
Session: Poster viewing 04