Abstract 140P
Background
Periampullary carcinoma accounts for over 30,000 cancer-related deaths per year in the US. The outcome of the disease differs according to the chosen modality of treatment. This study compared the survival rate between patients undergoing pancreaticoduodenectomy alone versus those receiving neoadjuvant chemotherapy before undergoing the surgery in stage II and III periampullary carcinoma.
Methods
Using the SEER database, we extracted the data of 868 patients with periampullary carcinoma from 2007 to 2011, aged between 40-79 years old. We selected patients with periampullary carcinomas who underwent pancreaticoduodenectomy alone compared to those received neoadjuvant chemotherapy before the surgery.
Results
The highest 5-year survival rate was observed in patients receiving neoadjuvant chemotherapy followed by pancreaticoduodenectomy (20.1%); especially those of stage II (20.1%). However, we found no significant difference in overall survival regarding the patients' gender or race.Table:
140P
| Variables | Overall survival | p-value |
|---|---|---|
| Therapy Surgery Combined | 17.3% 20.1% | 0.000** |
| Stage II III | 20.1% 7.9 % | 0.000** |
| Race White Black | 19.0% 22.7% | 0.732 |
| Sex Male Female | 19.3% 19.5% | 0.388 |
Highly significant p-value at ≤ 0.001 Combined: neoadjuvant chemotherapy and surgery.
Conclusions
Patients receiving neoadjuvant chemotherapy before pancreaticoduodenectomy had better 5-year overall survival compared to those undergoing pancreaticoduodenectomy alone; especially stage II.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Mai Abdelkader.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.
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