ESMO Asia Congress 2019

Abstract 307P

Background

Lacrimal gland is an exocrine secretory gland located at the upper temporal fossa of the orbit. It is part of the tear-forming apparatus that constitutes an important orbital structure. However, data available about tumors possibly originating in this site are scarce. In this study, we aimed to spotlight on this rare type of malignancy using the using data from American National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) Program.

Methods

We used SEER*Stat version 8.3.4, Microsoft Excel, as well as SPSS IBM SPSS Statistics for Windows, Version 21.0. In SEER*Stat, we used the (Incidence - SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2015 Sub (1973-2013 varying)) database. We included SEER 18 cases that were diagnosed after 2003 (2004+) in which the primary site was identified as (C69.5 – Lacrimal gland). Only cases with malignant behavior, known age, and those in the Research Database were included.

Results

A total of 491 cases were identified with a median age of 63. Females represented the majority of the analyzed cohort (n = 263, 53.6%). Lacrimal gland tumors were most common among the white race (n = 376, 76.6%). Age-adjusted Incidence rate was 0.6 per 1,000,000 with a median survival of 41 months, while 5-year relative survival was 88.4% (CI: 81.9% - 92.6%). The most common pathology of studied cases was Non-Hodgkin lymphoma (n = 254, 51.7%) (Table).Table:

307P Different pathological subtypes for lacrimal gland tumours

Pathological Subtype	N.	%
NHL-Mature B-Cell Lymphomas	254	51.7 %
Squamous Cell Neoplasms	71	14.5 %
Adenomas &Adenocarcinomas	64	13.0 %
Malignant Lymphomas, NOS Or Diffuse	32	6.5 %
Mucoepidermoid Neoplasms	17	3.5 %
Epithelial Neoplasms, NOS	10	2.0 %
Nevi Melanomas	8	1.6 %
Ductal & Lobular Neoplasms	7	1.4 %
Lymphoid Leukemias (C42.1)	6	1.2 %
Transitional Cell Papillomas & Carcinomas	4	0.8 %
Complex Mixed & Stromal Neoplasms	4	0.8 %
Myomatous Neoplasms	3	0.6 %
Basal Cell Neoplasms	2	0.4 %
Complex Epithelial Neoplasms	2	0.4 %
Plasma Cell Tumors	2	0.4 %
Unspecified Neoplasms	1	0.2 %
Cystic, Mucinous & Serous Neoplasms	1	0.2 %
Fibromatous Neoplasms	1	0.2 %
Hodgkin Lymphomas	1	0.2 %
Nhl-Mature T & Nk-Cell Lymphomas	1	0.2 %

Conclusions

Lacrimal gland tumors are extremely rare with incidence rate of 0.6 per million. These tumors are more likely to occur in old age, females, white race. 5-years relative survival is 88.4% with a median survival of 41 months.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

23 Nov 2019