Abstract 90P
Background
Immune surveillance is closely related to MHC and its associated molecules. The MHC class I chain related B molecule (MICB) is one of the ligands of NKG2D receptor. NKG2D receptor exists in NK cells and CD8+ T cells, which mediate anti-tumor response and immune surveillance. MICB is expressed by intestinal epithelium and epithelial tumors as well. Cancer cells express MICB as the consequence of cellular stress. But tumor cells might develop evasive pathways to avoid NK cell attack. Shedding is a way for cancer cells to remove or avoid the surface expression of MICB. Previous studies haven’t clearly figured out the prognostic value of MICB in colorectal cancer (CRC). Here, we figured out the relationship between MICB and prognosis in a CRC cohort of Zhongshan Hospital. The prognostic benefit was also validated in GSE39582 from Gene Expression Omnibus repository.
Methods
863 consecutive CRC patients from 2008 to 2012 without prior treatment were enrolled. 556 CRC patients between 1987 to 2007 were collected from GSE39582. MICB was detected by immunochemistry. MICB score equaled MICB intensity multiplied by the percentage of positive cells among all tumor cells. The cut-off value of MICB score was calculated by X-tile. The association between clinicopathological features and MICB were accessed by chi-square test. Kaplan-Meier analysis and log-rank test were performed to evaluate the relationship between MICB and overall survival. Univariate and multivariate cox regression analyses were performed to identify the independent prognostic factors.
Results
High MICB was significantly associated with non-mucinous histological type (p < 0.001) and ≤4.0cm tumor size (p = 0.001). Kaplan-Meier analyses and log-rank test showed high MICB group had a better overall survival (p = 0.002). In cox regression analyses of Zhongshan cohort, MICB was confirmed as an independent prognostic factor of OS (p = 0.008, HR = 0.741, 95% CI = 0.594-0.924).
Conclusions
MICB was identified as a new independent prognostic factor in stage one to stage four CRC patients. CRC with high MICB expression conferred survival benefit.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Zhongshan Hospital, Fudan University, Shanghai, China.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.
Resources from the same session
134P - Identification, development and validation of a circulating miRNA-based diagnostic signature for early detection of gastric cancer
Presenter: Daisuke Izumi
Session: Poster display session
Resources:
Abstract
135P - The promising key genes associated with tumour microenvironment and prognosis of hepatocellular carcinoma
Presenter: Jing Fang
Session: Poster display session
Resources:
Abstract
136P - Helicobacter pylori-positive gastric diffuse large B-cell lymphoma: A subset with distinct prognostic features
Presenter: Yuan Cheng
Session: Poster display session
Resources:
Abstract
137P - Significant benefit of pyrotinib combined with SHR6390 in patients with multiline-resistant HER2-positive advanced gastric cancer
Presenter: Zuhua Chen
Session: Poster display session
Resources:
Abstract
138P - Incidence of supracarinal lymph node positivity in operated cases of total esophagectomy: Short term results from a tertiary cancer centre
Presenter: Akhil Palod
Session: Poster display session
Resources:
Abstract
139P - Prognostic usefulness of advanced lung cancer inflammation index in locally-advanced pancreatic carcinoma patients treated with radical chemoradiotherapy
Presenter: Ayberk Besen
Session: Poster display session
Resources:
Abstract
140P - Pancreaticoduodenectomy versus combined neoadjuvant chemotherapy and pancreaticoduodenectomy: Survival patterns among patients with stage II & III periampullary carcinoma
Presenter: Mai Abdelkader
Session: Poster display session
Resources:
Abstract
141P - A 13-gene signature of DNA repair predicts prognosis in gastric cancer patients
Presenter: Jinjia Chang
Session: Poster display session
Resources:
Abstract
142P - Relation between Interleukin -4 (590C/T) gene polymorphism and hepatocellular carcinoma risk in HBV and HCV patients
Presenter: Suzy Gohar
Session: Poster display session
Resources:
Abstract
143P - NOTCH3 expression predicts poor survival in advanced esophageal squamous cell cancers
Presenter: Raja Pramanik
Session: Poster display session
Resources:
Abstract