Abstract 177P
Background
Ramcirumab (RAM) plus paclitaxel (PTX) is the standard second-line chemotherapy for metastatic gastric cancer. The ABSOLUTE trial showed that weekly nanoparticle albumin-bound (nab)-PTX was non-inferior to weekly PTX in terms of overall survival (OS). [Objective] This study aimed to evaluate the efficacy and safety of nab-PTX plus RAM compared with PTX plus RAM in metastatic gastric cancer patients, retrospectively.
Methods
Patients who received RAM plus nab-PTX or PTX in our institution from August 2015 to December 2018 were included in this retrospective study. (PTX plus RAM patients were administered from August 2015 to April 2018, and nab-PTX plus RAM patients received the combination from May 2018 to December 2018). Response rate, progression-free survival (PFS), OS and safety were assessed.
Results
A total of 79 patients were included in this study (24 in the nab-PTX plus RAM group and 55 in the PTX plus RAM group). Among the 17 patients with measurable lesions in the nab-PTX plus RAM group, 6 achieved PR (an objective response rate of 35%). Among the 38 patients with measurable lesions in the PTX plus RAM group, 8 achieved PR (an objective response rate of 21%). There was no significant difference between the two groups (p = 0.26), but nab-PTX plus RAM tended to produce a higher response rate than PTX plus RAM. The PFS was 5.7 months in the nab-PTX plus RAM group and 5.1 months in the PTX plus RAM group (p = 0.12). OS was not reached in the nab-PTX plus RAM group and was 8.6 months in the PTX plus RAM group (p = 0.27). The improvement rate of ascites did not differ between the two groups (38.4% in the nab-PTX plus RAM group and 40% in the PTX plus RAM group). Neutropenia was the most common grade 3 or 4 hematological toxicity, and there was no difference between the two groups (58.3% in the nab-PTX plus RAM group and 58.2% in the PTX plus RAM group). The incidence of any grade 3 or 4 non-hematological toxicity were also not different between the two groups.
Conclusions
This study suggests that nab-PTX plus RAM had almost similar efficacy and safety compared with PTX plus RAM in patients with metastatic gastric cancer.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
117P - Short-term and long-term outcomes of hepatectomy combined with intraoperative radiofrequency ablation for multiple colorectal liver metastases: A propensity score matching study
Presenter: Wenbai Huang
Session: Poster display session
Resources:
Abstract
119P - The impacts of dose-time-fractionation schedules on pathological complete response rate (pCR) and local recurrence (LR)
Presenter: Fu Jin
Session: Poster display session
Resources:
Abstract
120P - Platelet to lymphocyte ratio is associated with tumour localization and outcomes in patients with metastatic colorectal cancer
Presenter: Ahmet Bilici
Session: Poster display session
Resources:
Abstract
121P - Meta-analysis of three-dimensional versus two-dimensional laparoscopic surgery for rectal cancer
Presenter: Laiyuan Li
Session: Poster display session
Resources:
Abstract
127P - Outcomes based on albumin‐bilirubin (ALBI) grade in the phase III CELESTIAL trial of cabozantinib versus placebo in patients with advanced hepatocellular carcinoma (HCC)
Presenter: Stephen Chan
Session: Poster display session
Resources:
Abstract
128P - Tislelizumab in combination with chemotherapy for Chinese patients (Pts) with gastric/gastroesophageal junction cancer (GC/GEJC) or esophageal squamous cell carcinoma (ESCC)
Presenter: Yuxian Bai
Session: Poster display session
Resources:
Abstract
129P - Monitoring patient-specific mutation in ctDNA and CTC for tumour response evaluation after neoadjuvant chemotherapy in advanced gastric adenocarcinoma (NCT03425058)
Presenter: Tao Fu
Session: Poster display session
Resources:
Abstract
130P - Development of a liver cancer risk prediction model for the general population in china: A potential tool for screening
Presenter: Xiaoshuang Feng
Session: Poster display session
Resources:
Abstract
131P - Cabozantinib in Asian patients with hepatocellular carcinoma and other solid tumours: Population pharmacokinetics analysis
Presenter: Chih-Hung Hsu
Session: Poster display session
Resources:
Abstract
132P - Liposomal irinotecan (nal-IRI) plus 5-fluorouracil/levoleucovorin (5 FU/LV) vs 5-FU/LV in Japanese patients (pts) with gemcitabine-refractory metastatic pancreatic cancer (mPAC)
Presenter: Tatsuya Ioka
Session: Poster display session
Resources:
Abstract