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Poster display session

YO34 - A rare endocrinological syndrome presenting with weakness in Soft tissue sarcoma - a Case report


23 Nov 2019


Poster display session


Supportive Care and Symptom Management

Tumour Site

Soft Tissue Sarcomas


Rahul D. Arora


R.D. D. Arora

Author affiliations

  • Palliative Medicine, All India Institute of Medical Sciences, 110029 - Delhi/IN


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Abstract YO34

Case summary


Alteration in Urinary phosphate levels has been considered to be a paraneoplastic syndrome. This case report sheds light on a rare endocrinological cause of limb weakness.

Case details

A 31 year old female, a known case of pleomorphic leiomyosarcoma post surgery, post adjuvant chemotherapy with recently diagnosed parenchymal and pleural deposits presented with weakness in legs since the past 3 days, abnormal movements involving both the arms since the past 1 day and altered sensorium since the past 2 days. There was no history of symptoms of raised intracranial tension or metastatic spinal cord compression. Examination revealed reduced power in both the upper and lower limbs with downgoing flexors. Further investigation revealed reduced levels of serum phosphate, serum calcium and transaminiitis. Based upon recent reports available with the patient, vitamin D levels were found to be low whereas Intact PTH was found to be normal. A diagnosis of tumor induced osteomalacia versus Pazopanib induced fanconi’s syndrome was considered. She was started on oral phosphate supplements and vitamin D.


Tumor induced osteomalacia needs to be recognized as a reversible causes of quadriparesis in the advanced cancer population with mesenchymal tumours. The diagnosis was made in the Palliative medicine ward in the absence of 24 hour urinary phosphate levels or serum FGF levels.

Laboratory parameters 24-01-2019 25-01-2019
Total Calcium 1.9 1.5
Serum Urea 20 17
Serum Creatinine 0.5 0.4
Serum Uric Acid 3.5
Serum Sodium 134
Serum Potassium 3.03
Serum Chloride 105.8
Serum PTH 71.90
Serum Vitamin D3 12.26
Total leucocyte count 1070 900
Serum Haemoglobin 13.2 9.7
QTc interval (corrected)
Bazette's 0.5 0.47
Frederica's 0.49 0.46
Framingham 0.52 0.46
Hodges 0.52 0.45

Clinical trial identification

Editorial acknowledgement

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