Chapter 1 - Epidemiology, Pathogenesis and Risk Factors of Brain Tumours
- Primary CNS tumours are diverse histological entities with different causes
- Primary CNS tumours include malignant, benign and borderline tumours
- Meningiomas and gliomas are the two main histological types of primary CNS tumours
- Secondary CNS tumours (metastases) are more frequent than primary CNS tumours
- Glioblastoma is the most frequent glioma with a median age at diagnosis of 64 years
- Paediatric primary CNS tumour is the most frequent paediatric solid tumour
- Age, Karnofsky performance status, comorbidity, tumour growth rate, magnetic resonance imaging, histology and biology are important prognostic factors
- Symptomatology and QoL must be taken into account in the medical care management
- High-dose ionising radiation is the only unequivocal risk factor that was identified for glial and meningeal neoplasms
- Increased risk of glioma and meningioma is observed in rare hereditary syndromes
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