Case 5
An 81-year-old male was diagnosed with colorectal carcinoma of the transverse colon.
NTRK gene fusion testing
IHC screening was positive for TRKA, TRKB, and TRKC.
Pan-TRK IHC of Patient with Colon Adenocarcinoma
Antibody for IHC: clone EPR17341 available from Abcam, Cambridge, MA, USA(www.abcam.com)
Presence of the ETV6-NTRK3 gene fusion was confirmed by NGS. No mutations or copy number variations were detected using the Oncomine Focus AssayTM.
TRK inhibitor treatment
The patient was not treated with a TRK inhibitor.
Clinical interpretation and impact of NTRK gene fusion testing
Half of cases with NTRK3-ETV6 gene fusions have nuclear staining by IHC [1].
References
- Hechtman JF, Benayed R, Hyman DM et al. Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions. Am J Surg Pathol 2017; 41: 1547-1551.