Abstract 161P
Background
Targeted therapy and Immunotherapy have revolutionized the treatment of metastatic non-small cell lung cancer (NSCLC), particularly adenocarcinoma (AC). Among NSCLC cases, around 8-10% are ALK positive with the majority involving EML4-ALK gene variants. This study aims to explore the connection between ALK gene variants and PDL1 expression in metastatic lung AC, as there is limited data from the Indian cohort on this subject.
Methods
A retrospective analysis was conducted on data collected from 17 advanced lung AC patients with ALK gene mutations. The ALK protein variants were determined through Next-Generation Sequencing, while PDL1 expression was assessed using Immunohistochemistry with sP263 antibody. These findings were then correlated with relevant clinical parameters.
Results
The median age of the patient cohort was 46 years (range 28 to 65). Among the 17 ALK-positive, the majority had EML4-ALK gene fusions, with V1 (47.05%), V3 (35.2%), and V2 (11.7%) being the most common variants. V1 was more prevalent in females (87.5%) than males (12.5%). PDL1 negativity was observed in 64.7% of patients, while 35.2% were PDL1 positive. Specifically, PDL1 negativity was more common in the V1 variant, whereas PDL1 positivity was associated with V3. Brain metastases were more frequent in the PDL1-negative cohort (35.2%), and bone metastases and malignant pleural effusions were more common in V1 compared to V2 and V3. Table: 161P
ALK metastatic sites | Frequency |
Malignant pleural effusion | 70.5% |
Brain metastasis | 35.2% |
Bone metastasis | 35.2% |
Contralateral lung involvement | 23.5% |
Liver metastasis | 11.7% |
Conclusions
The study concludes that V1 and V3 EML4-ALK gene variants are prevalent in metastatic lung AC patients. It reveals a significant association between PDL1 expression and specific ALK variants, with V1 being more frequently associated with PDL1 negativity and V3 with PDL1 positivity. Additionally, the V1 and V3 variants were more commonly found in female patients and were associated with brain metastases. This real-world experience contributes valuable insights into treatment responses in this specific patient population.
Editorial acknowledgement
Clinical trial identification
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
134P - Doxorubicin and olaparib (OLA) synergism in high-grade serous ovarian (HGOC) and triple-negative breast cancer (TNBC) cell lines with olaparib-resistance
Presenter: Jose Alejandro Perez Fidalgo
Session: Cocktail & Poster Display session
Resources:
Abstract
136P - Molecular correlates of drug response to guide therapy in TNBC
Presenter: Nathan Merrill
Session: Cocktail & Poster Display session
Resources:
Abstract
137P - Event-free survival prediction using lncRNAs in pediatric B-cell acute lymphoblastic leukemia
Presenter: Unai Illarregi
Session: Cocktail & Poster Display session
Resources:
Abstract
138P - Exome sequencing analysis for the identification of actionable mutations related to neoadjuvant chemotherapy response in locally advanced breast cancer
Presenter: Ximena López
Session: Cocktail & Poster Display session
Resources:
Abstract
139P - Genomic prognostic and potential theragnostic factors in anal squamous cell carcinoma treated with abdominoperineal resection
Presenter: Abderaouf Hamza
Session: Cocktail & Poster Display session
Resources:
Abstract
144P - Correlation of EZH2 expression and response to chemoradiotherapy in patients with locally advanced inoperable oral cavity and oropharyngeal squamous cell cancers
Presenter: Soel Ahmed
Session: Cocktail & Poster Display session
Resources:
Abstract
140P - Predictive value of DNA damage response and repair gene alterations and neoscore for neoadjuvant immunotherapies in non-small cell lung cancer
Presenter: Fei Feng
Session: Cocktail & Poster Display session
Resources:
Abstract
141P - Immune-related epigenomic and transcriptomic signatures to predict immunotherapy response in NSCLC
Presenter: María Gallardo-Gómez
Session: Cocktail & Poster Display session
Resources:
Abstract
142P - Role and impact of hypoxia-inducible factor 1-alpha on survival rates in pancreatic cancer: A systematic review and meta-analysis
Presenter: Muhammed Elfaituri
Session: Cocktail & Poster Display session
Resources:
Abstract
143P - Genomic characterization and outcomes of patients with primary sclerosing cholangitis-related cholangiocarcinoma
Presenter: Jaime Haro Silerio
Session: Cocktail & Poster Display session
Resources:
Abstract