Abstract 182P
Background
Lung cancer in Spain is the first leading cause of cancer mortality in men and the third in women. This study analyzes the evolution of lung cancer mortality in Spain for both sexes from 1980 to 2022.
Methods
Lung cancer mortality data (ICD-10: C33-C34) and the population needed to calculate lung cancer mortality rates were obtained from the National Institute of Statistics. Lung cancer mortality rates were calculated for the years 1980 to 2022, both crude and age-adjusted using the direct method. Joinpoint regression models were used to analyze the trend of the adjusted rates. Annual percentage changes (APC) and their 95% confidence intervals (95%CI) were calculated.
Results
From 1980 to 2022, lung cancer caused 745,182 deaths in Spain, with 84.9% (632,907 deaths) occurring in men and 15.1% (112,275 deaths) occurring in women. The crude mortality rate for lung cancer in men increased until the beginning of the 21st century and has since stabilized. The crude mortality rate for men increased by 73.9%, from 41.5 deaths per 100,000 population in 1980 to 72.1 deaths in 2022. The mortality rate among women increased by 300.3% over the same period, rising from 6.2 deaths per 100,000 population in 1980 to 24.7 deaths in 2022. When analyzing the trend of the adjusted rates in men, three periods were detected. The first period showed an increasing trend between 1980-1993 (APC = 2.7 [95%CI 2.4 to 2.9]). The second and third periods both showed a decreasing trend; the first between 1993-2006 (APC = -0.6 [95%CI -0.9 to -0.3)], and the second between 2006-2022 (APC = -1.8 [95%CI -2.0 to -1.6]). In women, three periods were also detected. During the period of 1980-1989, there was a decreasing trend (APC = -1.0 [95%CI -1.7 to -0.3]). Between 1989-1999 and 1999-2022, there was an increasing trend in lung cancer mortality rates (APC: 1989-1999 = 1.6 [95%CI 0.9 to 2.3]; APC: 1999-2022 = 3.8 [95%CI 3.6 to 4.0]).
Conclusions
In recent years, lung cancer mortality rate has increased in Spanish women, while in men has stabilized. The adjusted rates show a decrease in men, which may explain the stabilization observed in the crude rates due to the aging of the population. The rate of increase in lung cancer death rates in women has doubled since 1999, highlighting the need for immediate preventive measures to curb this trend.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.