Abstract 152P
Background
Cancer is the primary cause of work-related death in Europe (52%). Lung cancer (LC) is one of the most common tumors linked to occupational exposure, although the real prevalence and its clinical profile remains unknown. We aim to study the occupations and patient's profile in a real-world data cohort of NSCLC.
Methods
Prospective study of patients (pts) with all-stages NSCLC treated at Hospital Clinic (Spain) between 2020-present. A personal interview was performed to collect demographic, smoking habit, environmental, cancer history and occupation data. Clinical data was collected from medical reports. Up to 4 jobs were collected for each patient, according to the Spanish National Classification (CNO11), including duration/workplace and occupational exposure.
Results
In the first 168 pts enrolled, median age was 67 years (yrs), 60% male, 87% smokers; 62% had stage IV with mainly adenocarcinoma histology (70%); 60% with a driver alteration. Two out of 3 had high education level; 50% were retired at diagnosis. In our area (city center) the main occupations were: commerce [15%] (60% males; 96% smokers), public services [11%] (44% males; 28% smokers) and mechanical engineering [11%] (83% males; all smokers). Diagnosis before 65 yrs was observed in 75% of construction (6) and 100% of agriculture workers (2) vs. 14% in the tourism sector or none in housekeepers. Occupations related to potential carcinogens exposure were exclusively seen in males (construction, industries), with high smoking rates (75–100%). In contrast, health workers were mainly females (71%) and all housekeepers were females, with lower smoking rates (33%-88%). Regardless of the occupation, adenocarcinoma was the predominant histology; with higher ratio of squamous seen in textile, mechanical, metal/chemical sectors (20–37%).
Conclusions
In our preliminary data, differences on occupational profile were identified in NSCLC. Male smokers were observed in occupations with potential exposure to carcinogens. Deeper characterization of occupation and its clinical impact could improve the work-related LC prevention.
Legal entity responsible for the study
Hospital Clinic y Provincial de Barcelona.
Funding
Has not received any funding.
Disclosure
N. Reguart: Financial Interests, Personal, Invited Speaker: MSD, BMS, Roche, Guardant Health, Pfizer, AbbVie, Ipsen, Novartis, AstraZeneca, Eli Lilly, Takeda, Amgen; Financial Interests, Personal, Advisory Role: MSD, BMS, Roche, Guardant Health, Pfizer, AbbVie, Ipsen, Novartis, AstraZeneca, Eli Lilly, Takeda, Amgen. L. Mezquita: Financial Interests, Personal, Research Grant: Bristol Myers Squibb, Boehringer Ingelheim, Amgen, Stilla, Inivata, AstraZeneca; Financial Interests, Personal, Advisory Board: Roche, Takeda; Financial Interests, Personal, Training: Bristol Myers Squibb, Takeda, Foundation Medicine, Janssen; Financial Interests, Personal, Other, Travel/Accommodation: Roche, Takeda, Bristol Myers Squibb, Janssen. All other authors have declared no conflicts of interest.